Mammalian mitochondrial IAP binding proteins

被引：192

作者：

Vaux, DL ^{[1
]}

Silke, J ^{[1
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 304卷 / 03期

关键词：

Diablo; Smac; HtrA2; Omi; IAP; caspase; reaper; grim; HID;

D O I：

10.1016/S0006-291X(03)00622-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four mitochondrial proteins have been identified that immunoprecipitate with the mammalian inhibitor of apoptosis (IAP) protein XIAP. Each of them interacts via a processed amino terminus that resembles those of the insect pro-apoptotic TAP binding proteins Grim, HID, Reaper, and Sickle. Two, Diablo/Smac and HrtA2/Omi, have been extensively characterized. Both Diablo and HtrA2 can bind to IAPs and promote apoptosis when over-expressed in transfected cells, but unlike the insect IAP antagonists, to date there is scant evidence that they are important regulators of apoptosis in more physiological circumstances. (C) 2003 Elsevier Science (USA). All rights reserved.

引用

页码：499 / 504

页数：6

共 50 条

[21] A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing Proteins
Schwalm, Martin P.
Berger, Lena M.
Meuter, Maximilian N.
Vasta, James D.
Corona, Cesear R.
Roehm, Sandra
Berger, Benedict-Tilman
Farges, Frederic
Beinert, Sebastian M.
Preuss, Franziska
Morasch, Viktoria
Rogov, Vladimir V.
Mathea, Sebastian
Saxena, Krishna
Robers, Matthew B.
Mueller, Susanne
Knapp, Stefan
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022, 10
[22] Analysis of candidate antagonists of IAP-mediated caspase inhibition using yeast reconstituted with the mammalian Apaf-1-activated apoptosis mechanism
C. J. Hawkins
J. Silke
A. M. Verhagen
R. Foster
P. G. Ekert
D. M. Ashley
Apoptosis, 2001, 6 : 331 - 338
[23] Analysis of candidate antagonists of IAP-mediated caspase inhibition using yeast reconstituted with the mammalian Apaf-1-activated apoptosis mechanism
Hawkins, CJ
Silke, J
Verhagen, AM
Foster, R
Ekert, PG
Ashley, DM
APOPTOSIS, 2001, 6 (05) : 331 - 338
[24] Mitochondrial death pathways in yeast and mammalian cells
Cheng, Wen-Chih
Leach, Kelly M.
Hardwick, J. Marie
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2008, 1783 (07): : 1272 - 1279
[25] Mitochondrial proteins in neuronal degeneration
Lindholm, D
Eriksson, O
Korhonen, L
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 321 (04) : 753 - 758
[26] Structure-based design and synthesis of tricyclic IAP (Inhibitors of Apoptosis Proteins) inhibitors
Hird, Alexander W.
Aquila, Brian M.
Block, Michael H.
Hennessy, Edward J.
Kamhi, Victor M.
Omer, Charles A.
Laing, Naomi M.
Saeh, Jamal C.
Sha, Li
Yang, Bin
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (07) : 1820 - 1824
[27] Expression of IAP-family proteins in adult acute mixed lineage leukemia (AMLL)
Nakagawa, Y
Hasegawa, M
Kurata, M
Yamamoto, K
Abe, S
Inoue, M
Takemura, T
Hirokawa, K
Suzuki, K
Kitagawa, M
AMERICAN JOURNAL OF HEMATOLOGY, 2005, 78 (03) : 173 - 180
[28] Expression of IAP family proteins in colon cancers from patients with different age groups
Endo, T
Abe, S
Seidlar, HBK
Nagaoka, S
Takemura, T
Utsuyama, M
Kitagawa, M
Hirokawa, K
CANCER IMMUNOLOGY IMMUNOTHERAPY, 2004, 53 (09) : 770 - 776
[29] Inhibition of Bcl-2 or IAP proteins does not provoke mutations in surviving cells
Shekhar, Tanmay M.
Green, Maja M.
Rayner, David M.
Miles, Mark A.
Cutts, Suzanne M.
Hawkins, Christine J.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2015, 777 : 23 - 32
[30] Expression of IAP family proteins in colon cancers from patients with different age groups
T. Endo
S. Abe
H. B. K. Seidlar
S. Nagaoka
T. Takemura
M. Utsuyama
M. Kitagawa
K. Hirokawa
Cancer Immunology, Immunotherapy, 2004, 53 : 770 - 776

← 1 2 3 4 5 →