Ziprasidone suppresses olanzapine-induced increases in ingestive behaviour in the rat

被引：33
作者：
Kirk, SL
Neill, JC
Jones, DNC
Reynolds, GP
机构：
[1] Queens Univ Belfast, Dept Mental Hlth, Div Psychiat & Neurosci, Belfast BT9 7BL, Antrim, North Ireland
[2] Univ Bradford, Bradford Sch Pharm, Bradford BD7 1DP, W Yorkshire, England
[3] GlaxoSmithKline, Psychiat CEDD, Harlow CM19 5AW, Essex, England
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2004年 / 505卷 / 1-3期
关键词：
antipsychotic; weight gain; (Rat);
D O I：
10.1016/j.ejphar.2004.10.015
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Many atypical antipsychotic drugs, such as olanzapine, induce significant weight gain. However, ziprasidone produces minimal weight gain, the mechanism of which remains unclear. The aim of the present study was to investigate whether ziprasidone would reduce the acute effect of olanzapine on feeding behaviour. The results suggest that ziprasidone suppresses the significant increases in food intake produced by olanzapine, indicating that it has an intrinsic protective mechanism against drug-induced increases in food intake. (C) 2004 Elsevier B.V. All rights reserved.
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收藏
页码：253 / 254
页数：2
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