NON-NATURAL NUCLEOSIDES BASED ON 1,2,4-TRIAZOLO[1,5-a]PYRIMIDIN-7-ONES

被引：7

作者：

Chupakhin, Oleg N. ^{[1
,2
]}

Shestakova, Tatiana S. ^{[1
]}

Deev, Sergey L. ^{[1
]}

Eltsov, Oleg S. ^{[1
]}

Rusinov, Vladimir L. ^{[1
]}

机构：

[1] Ural State Tech Univ, Dept Organ Chem, Ekaterinburg 620002, Russia

[2] Russian Acad Sci, Inst Organ Synth, Ekaterinburg 620002, Russia

来源：

HETEROCYCLES | 2010年 / 80卷 / 02期

关键词：

Non-Natural Nucleoside; Nucleoside Analog; 1,2,4-Triazolo[1,5-a]pyrimidin-7-one; Glycosylation; Alkyl Fragment; ANALOGS; GLYCOSYLATION; INHIBITORS; POTENT;

D O I：

10.3987/COM-09-S(S)97

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two methods for synthesis of new nucleosides bearing 6-phenyl-1,2,4-triazolo[1,5-a]pyrimidin-7-ones as a base have been developed. The first one includes Vorbruggen glycosylation reaction. The second method, which is effective for synthesis of acyclic nucleosides, is based on the condensation between sodium salts of 6-phenyl-1,2,4-triazolo [1,5-a]pyrimidin-7-ones and 4-bromobuthyl acetate or (Z)-4-bromobut-2-en-1-yl acetate.

引用

页码：1149 / 1163

页数：15

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