Saliva sample for the massive screening of SARS-CoV-2 infection: a systematic review

被引：19

作者：

Canete, Martin Gonzalez ^{[1
]}

Valenzuela, Isidora Mujica ^{[2
]}

Garces, Patricia Carvajal ^{[3
]}

Masso, Isabel Castro ^{[3
]}

Gonzalez, Maria Julieta ^{[3
]}

Gonzalez, Sergio ^{[2
]}

机构：

[1] Univ Andes, Fac Dent, Ave Monsenor Alvaro del Portillo 12455, Santiago, Chile

[2] Univ Andes, Fac Dent, Dept Oral Pathol, Santiago, Chile

[3] Univ Chile, Inst Biomed Sci ICBM, Fac Med, Santiago, Chile

来源：

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY | 2021年 / 131卷 / 05期

关键词：

NASOPHARYNGEAL SWAB;

D O I：

10.1016/j.oooo.2021.01.028

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Objective. This systematic review aims to describe the value of saliva as a noninvasive sample for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in comparison with the current method for sample collection, the nasopharyngeal swab. Study Design. We conducted a systematic review of the literature following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. We searched in 5 databases (PubMed, Cochrane, EBSCO, Elsevier, and MEDLINE) and included articles published between December 2019 and July 2020. Results. This review included 22 publications that met inclusion criteria, 17 of which were case series, 2 of which were case reports, and 3 of which were massive screenings. All articles compared saliva with nasopharyngeal swabs. The detection rate of SARS-CoV-2 in saliva was similar to that for nasopharyngeal swabs. The sensitivity ranged between 20% and 97%, and specificity ranged between 66% and 100%. Conclusions. This systematic review found that saliva might be an appropriate, fast, painless, simple, and noninvasive sample for SARS-CoV-2 detection, making it ideal for massive screening of SARS-CoV-2 infection.

引用

页码：540 / 548

页数：9

共 48 条

[1] Two cases of COVID-19 with positive salivary and negative pharyngeal or respiratory swabs at hospital discharge: A rising concern [J].

Azzi, Lorenzo ;

Carcano, Giulio ;

Dalla Gasperina, Daniella ;

Sessa, Fausto ;

Maurino, Vittorio ;

Baj, Andreina .

ORAL DISEASES, 2021, 27 :707-709

[2] Saliva is a reliable tool to detect SARS-CoV-2 [J].

Azzi, Lorenzo ;

Carcano, Giulio ;

Gianfagna, Francesco ;

Grossi, Paolo ;

Dalla Gasperina, Daniela ;

Genoni, Angelo ;

Fasano, Mauro ;

Sessa, Fausto ;

Tettamanti, Lucia ;

Carinci, Francesco ;

Maurino, Vittorio ;

Rossi, Agostino ;

Tagliabue, Angelo ;

Baj, Andreina .

JOURNAL OF INFECTION, 2020, 81 (01) :E45-E50

[3]

Becker D, 2020, MEDRXIV, DOI 10.1101/2020.05.11.20092338

[4] Contact tracing in patients infected with SARS-CoV-2. The fundamental role of Primary Health Care and Public Health [J].

Bellmunt, J. M. ;

Cayla, J. A. ;

Millet, J. P. .

MEDICINA DE FAMILIA-SEMERGEN, 2020, 46 :62-71

[5]

Caulley L, 2020, ANN INTERN MED, V2, P2

[6] Evaluating the use of posterior oropharyngeal saliva in a point-of-care assay for the detection of SARS-CoV-2 [J].

Chen, Jonathan Hon-Kwan ;

Yip, Cyril Chik-Yan ;

Poon, Rosana Wing-Shan ;

Chan, Kwok-Hung ;

Cheng, Vincent Chi-Chung ;

Hung, Ivan Fan-Ngai ;

Chan, Jasper Fuk-Woo ;

Yuen, Kwok-Yung ;

To, Kelvin Kai-Wang .

EMERGING MICROBES & INFECTIONS, 2020, 9 (01) :1356-1359

[7]

Control ECfDPa, 2020, POP WID TEST SARS CO, P1

[8] Role of Saliva and Salivary Diagnostics in the Advancement of Oral Health [J].

Dawes, C. ;

Wong, D. T. W. .

JOURNAL OF DENTAL RESEARCH, 2019, 98 (02) :133-141

[9] Hyposalivation as a potential risk for SARS-CoV-2 infection: Inhibitory role of saliva [J].

Farshidfar, Nima ;

Hamedani, Shahram .

ORAL DISEASES, 2021, 27 :750-751

[10] Oral saliva and COVID-19 [J].

Fini, Maryam Baghizadeh .

ORAL ONCOLOGY, 2020, 108

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