New anti-inflammatory tocopherol- derived metabolites from the Taiwanese soft coral Cladiella hirsuta

被引：9

作者：

Chen, Bo-Wei ^{[1
]}

Uvarani, Chokkalingam ^{[1
]}

Huang, Chiung-Yao ^{[1
]}

Hwang, Tsong-Long ^{[2
]}

Dai, Chang-Feng ^{[3
]}

Sheu, Jyh-Horng ^{[1
,4
,5
,6
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[2] Chang Gung Univ, Grad Inst Nat Prod, Taoyuan 333, Taiwan

[3] Natl Taiwan Univ, Inst Oceanog, Taipei 112, Taiwan

[4] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[5] China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung 404, Taiwan

[6] Natl Sun Yat Sen Univ, Frontier Ctr Ocean Sci & Technol, Kaohsiung 804, Taiwan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2015年 / 25卷 / 01期

关键词：

Cladiella hirsuta; Hirsutaquinone; Anti-inflammatory activity; EUNICELLIN-BASED DITERPENOIDS; A-D; KREMPFI; DISCOVERY;

D O I：

10.1016/j.bmcl.2014.11.002

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new tocopherol-derived metabolites, hirsutocospiro A (1) and hirsutocoquinone A (2), were isolated from the soft coral Cladiella hirsuta. The structures of 1 and 2 were determined by extensive spectroscopic analysis. The in vitro anti-inflammatory activity of compounds 1 and 2 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils. Compound 1 was shown to exhibit significant anti-inflammatory activity. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：92 / 95

页数：4

共 21 条

[1] Eunicellin-based diterpenoids, australins A-D, isolated from the soft coral Cladiella australis [J].

Ahmed, AF ;

Wu, MH ;

Wang, GH ;

Wu, YC ;

Sheu, JH .

JOURNAL OF NATURAL PRODUCTS, 2005, 68 (07) :1051-1055

[2] Polyoxygenated diterpenoids of the eunicellin-type from the Chinese soft coral Cladiella krempfi [J].

Cai, You-Sheng ;

Yao, Li-Gong ;

Di Pascale, Antonio ;

Irace, Carlo ;

Mollo, Ernesto ;

Taglialatela-Scafati, Orazio ;

Guo, Yue-Wei .

TETRAHEDRON, 2013, 69 (09) :2214-2219

[3] Hirsutalins I-M, eunicellin-based diterpenoids from the soft coral Cladiella hirsuta [J].

Chen, Bo-Wei ;

Wang, Sheng-Yang ;

Huang, Chiung-Yao ;

Chen, Shu-Li ;

Wu, Yang-Chang ;

Sheu, Jyh-Horng .

TETRAHEDRON, 2013, 69 (10) :2296-2301

[4] Hirsutosterols A-G, polyoxygenated steroids from a Formosan soft coral Cladiella hirsuta [J].

Chen, Bo-Wei ;

Chang, Shu-Ming ;

Huang, Chiung-Yao ;

Su, Jui-Hsin ;

Wen, Zhi-Hong ;

Wu, Yang-Chang ;

Sheu, Jyh-Horng .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2011, 9 (09) :3272-3278

[5] Hirsutalins A-H, Eunicellin-Based Diterpenoids from the Soft Coral Cladiella hirsuta [J].

Chen, Bo-Wei ;

Chang, Shu-Ming ;

Huang, Chiung-Yao ;

Chao, Chih-Hua ;

Su, Jui-Hsin ;

Wen, Zhi-Hong ;

Hsu, Chi-Hsin ;

Dai, Chang-Feng ;

Wu, Yang-Chang ;

Sheu, Jyh-Horng .

JOURNAL OF NATURAL PRODUCTS, 2010, 73 (11) :1785-1791

[6] Discovery of New Eunicellin-Based Diterpenoids from a Formosan Soft Coral Cladiella sp. [J].

Chen, Tsung-Hung ;

Lu, Mei-Chin ;

Chang, Yu-Chia ;

Su, Yin-Di ;

Chen, Yu-Hsin ;

Lin, Nai-Cheng ;

Fang, Lee-Shing ;

Wu, Yang-Chang ;

Sung, Ping-Jyun .

MARINE DRUGS, 2013, 11 (11) :4585-4593

[7] Discovery of New Eunicellins from an Indonesian Octocoral Cladiella sp. [J].

Chen, Yung-Husan ;

Tai, Chia-Ying ;

Su, Yin-Di ;

Chang, Yu-Chia ;

Lu, Mei-Chin ;

Weng, Ching-Feng ;

Su, Jui-Hsin ;

Hwang, Tsong-Long ;

Wu, Yang-Chang ;

Sung, Ping-Jyun .

MARINE DRUGS, 2011, 9 (06) :934-943

[8] Cladieunicellins A-E, New Eunicellins from an Indonesian Soft Coral Cladiella sp. [J].

Chen, Yung-Husan ;

Tai, Chia-Ying ;

Kuo, Yueh-Hsiung ;

Kao, Chia-Ying ;

Li, Jan-Jung ;

Hwang, Tsong-Long ;

Fang, Lee-Shing ;

Wang, Wei-Hsien ;

Sheu, Jyh-Horng ;

Sung, Ping-Jyun .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2011, 59 (03) :353-358

[9] Cladielloides A and B: New Eunicellin-Type Diterpenoids from an Indonesian Octocoral Cladiella sp. [J].

Chen, Yung-Husan ;

Tai, Chia-Ying ;

Hwang, Tsong-Long ;

Weng, Ching-Feng ;

Li, Jan-Jung ;

Fang, Lee-Shing ;

Wang, Wei-Hsien ;

Wu, Yang-Chang ;

Sung, Ping-Jyun .

MARINE DRUGS, 2010, 8 (12) :2936-2945

[10] Two novel α-tocopheroids from the aerial roots of Ficus microcarpa [J].

Chiang, YM ;

Kuo, YH .

TETRAHEDRON LETTERS, 2003, 44 (27) :5125-5128

← 1 2 3 →