The antioxidant and antigenotoxic potential of methanol extract of Cladonia foliacea (Huds.) Willd

被引：9

作者：

Anar, Mustafa ^{[1
]}

Orhan, Furkan ^{[2
,3
]}

Alpsoy, Lokman ^{[4
]}

Gulluce, Medine ^{[3
]}

Aslan, Ali ^{[1
]}

Agar, Guleray ^{[3
]}

机构：

[1] Ataturk Univ, Dept Biol Educ, Kazim Karabekir Fac Educ, Erzurum, Turkey

[2] Ibrahim Cecen Univ Agri, Cent Res & Applicat Labs, TR-04100 Agri, Turkey

[3] Ataturk Univ, Dept Biol, Fac Sci, Erzurum, Turkey

[4] Fatih Univ, Dept Biol, Fac Sci, Istanbul, Turkey

来源：

TOXICOLOGY AND INDUSTRIAL HEALTH | 2016年 / 32卷 / 04期

关键词：

Cladonia foliacea; antigenotoxicity; antioxidant enzymes; Ames; SCE; WP2; LYMPHOCYTES IN-VITRO; ANTIMICROBIAL PROPERTIES; OXIDIZED GLUTATHIONE; MUTAGENICITY ASSAY; CYTOTOXIC ACTIVITY; ESCHERICHIA-COLI; OXIDATIVE STRESS; LICHEN EXTRACTS; PROTECTIVE ROLE; CELL-LINES;

D O I：

10.1177/0748233713504805

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

In this article, the genotoxic and antigenotoxic effects of methanol extract of of Cladonia foliacea (Huds.) Willd. (CME) were studied using WP2, Ames (TA1535 and TA1537), and sister chromatid exchange (SCE) test systems. The results of our studies showed that 5 mu M concentration of aflatoxin B-1(AFB(1)) changed the frequencies of SCE and malondialdehyde (MDA) levels, superoxide dismutase (SOD), glutathione (GSH), and glutathione peroxidase (GPx) activities. When 5 and 10 mu g/mL concentrations of CME was added to AFB(1), the frequencies of SCE and MDA level were decreased and SOD, GSH, and GPx levels were increased. The extract CME did not show any mutagenicity on Ames (Salmonella typhimurium TA1535, TA1537) and WP2 (Escherichia coli) test systems. On the other hand, CME has antimutagenicity on the mentioned test systems. The results of this experiment have clearly shown that CME has a significant antioxidative and antigenotoxic effect, which is thought to be due to the antigenotoxic activities of antioxidant enzymes.

引用

页码：721 / 729

页数：9

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