Magnetically driven helical hydrogel micromotor for tumor DNA detection

被引：18
|
作者：
Qin, Fengying [1 ]
Wu, Juanyan [2 ]
Fu, Dongmei [1 ]
Feng, Ye [1 ]
Gao, Chao [1 ]
Xie, Dazhi [1 ]
Fu, Shaoming [1 ]
Liu, Suyi [1 ]
Wilson, Daniela A. [3 ]
Peng, Fei [1 ]
机构：
[1] Sun Yat Sen Univ, Sch Mat Sci & Engn, Guangzhou 510275, Peoples R China
[2] Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Peoples R China
[3] Radboud Univ Nijmegen, Inst Mol & Mat, NL-6525 AJ Nijmegen, Netherlands
来源：
APPLIED MATERIALS TODAY | 2022年 / 27卷
基金：
中国国家自然科学基金;
关键词：
Magnetic propulsion; Helical micromotor; Fluorescent probe; tumor DNA detection; SYBR GREEN I; CANCER; MICROMACHINES; NANOPARTICLES; MICROROBOTS; BIOMARKERS; PROGNOSIS; ASSAY; SWIM;
D O I：
10.1016/j.apmt.2022.101456
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
The DNA released by apoptotic tumor cells is one of the cancer markers, which can be used for early diagnosis, and prognosis evaluation. How to detect tumor DNA in a non-invasive, quick, and simple manner is attracting booming research enthusiasm. Here, we proposed a DNA detection system based on a magnetic helical hydrogel (PVA/MA/Fe3O4) micromotor incorporating fluorescent probe SYBR Green. Combining the precise navigation capabilities of the magnetically driven helical micromotor with high sensitivity of nucleic acid dyes, the micromotor-based fluorescent probing system not only exhibits excellent controllable moving performance, but also responds to the DNA released by apoptotic tumor cells with high efficiency, holding great promise for directed DNA detection.(c) 2022 Elsevier Ltd. All rights reserved.
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页数：9
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