Importance of Increased Arterial Resistance in Risk Prediction in Patients with Cardiovascular Risk Factors and Degenerative Aortic Stenosis

被引:10
作者
Baran, Jakub [1 ]
Kleczynski, Pawel [1 ]
Niewiara, Lukasz [1 ,2 ]
Podolec, Jakub [1 ]
Badacz, Rafal [1 ]
Gackowski, Andrzej [3 ,4 ]
Pieniazek, Piotr [1 ,5 ]
Legutko, Jacek [1 ]
Zmudka, Krzysztof [1 ]
Przewlocki, Tadeusz [1 ,5 ]
Kablak-Ziembicka, Anna [1 ,4 ]
机构
[1] Jagiellonian Univ Med Coll, Inst Cardiol, John Paul II Hosp, Dept Intervent Cardiol, PL-31202 Krakow, Poland
[2] Jagiellonian Univ Med Coll, Dept Emergency Med, Fac Hlth Sci, PL-31126 Krakow, Poland
[3] Jagiellonian Univ Med Coll, Inst Cardiol, John Paul II Hosp, Dept Coronary Dis & Heart Failure, PL-31202 Krakow, Poland
[4] John Paul 2 Hosp, Noninvas Cardiovasc Lab, PL-31202 Krakow, Poland
[5] Jagiellonian Univ Med Coll, Inst Cardiol, John Paul II Hosp, Dept Cardiac & Vasc Dis, PL-31202 Krakow, Poland
关键词
cardiovascular risk factors; heart failure; major cardiac and cerebral ischemic events; degenerative aortic stenosis; risk stratification; vascular resistance; INTIMA-MEDIA THICKNESS; STIFFNESS; SEVERITY; PRESSURE;
D O I
10.3390/jcm10102109
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Cardiovascular disease is a leading cause of heart failure (HF) and major adverse cardiac and cerebral events (MACCE). Objective: To evaluate impact of vascular resistance on HF and MACCE incidence in subjects with cardiovascular risk factors (CRF) and degenerative aortic valve stenosis (DAS). Methods: From January 2016 to December 2018, in 404 patients with cardiovascular disease, including 267 patients with moderate-to-severe DAS and 137 patients with CRF, mean values of resistive index (RI) and pulsatile index (PI) were obtained from carotid and vertebral arteries. Patients were followed-up for 2.5 years, for primary outcome of HF and MACCE episodes. Results: RI and PI values in patients with DAS compared to CRF were significantly higher, with optimal cut-offs discriminating arterial resistance of >= 0.7 for RI (sensitivity: 80.5%, specificity: 78.8%) and >= 1.3 for PI (sensitivity: 81.3%, specificity: 79.6%). Age, female gender, diabetes, and DAS were all independently associated with increased resistance. During the follow-up period, 68 (16.8%) episodes of HF-MACCE occurred. High RI (odds ratio 1.25, 95% CI 1.13-1.37) and PI (odds ratio 1.21, 95% CI 1.10-1.34) were associated with risk of HF-MACCE. Conclusions: An accurate assessment of vascular resistance may be used for HF-MACCE risk stratification in patients with DAS.
引用
收藏
页数:10
相关论文
共 50 条
[41]   Cardiovascular risk factors and noninvasive assessment of arterial structure and function in obese Turkish children [J].
Yilmazer, Murat Muhtar ;
Tavli, Vedide ;
Carti, Oezguer Umac ;
Mese, Timur ;
Guven, Baris ;
Aydin, Banu ;
Devrim, Ilker ;
Tavli, Talat .
EUROPEAN JOURNAL OF PEDIATRICS, 2010, 169 (10) :1241-1248
[42]   Assessment of Cardiovascular Risk Factors in Patients with Psoriasis [J].
Komorowska, Olivia ;
Bohdan, Michal ;
Szczerkowska-Dobosz, Aneta ;
Rawicz-Zegrzda, Dorota ;
Dudziak, Maria ;
Zdrojewski, Tomasz ;
Gruchala, Marcin ;
Purzycka-Bohdan, Dorota ;
Nowicki, Roman .
ACTA DERMATOVENEROLOGICA CROATICA, 2016, 24 (04) :261-267
[43]   Cardiovascular risk factors and arterial rigidity are similar in asymptomatic normocalcemic and hypercalcemic primary hyperparathyroidism [J].
Tordjman, Karen M. ;
Yaron, Marianna ;
Izkhakov, Elena ;
Osher, Etty ;
Shenkerman, Galina ;
Marcus-Perlman, Yonit ;
Stern, Naftali .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2010, 162 (05) :925-933
[44]   Association of worsening arterial stiffness with incident heart failure in asymptomatic patients with cardiovascular risk factors [J].
Hiroe Aisu ;
Makoto Saito ;
Shinji Inaba ;
Toru Morofuji ;
Kayo Takahashi ;
Takumi Sumimoto ;
Takafumi Okura ;
Jitsuo Higaki .
Hypertension Research, 2017, 40 :173-180
[45]   Association of worsening arterial stiffness with incident heart failure in asymptomatic patients with cardiovascular risk factors [J].
Aisu, Hiroe ;
Saito, Makoto ;
Inaba, Shinji ;
Morofuji, Toru ;
Takahashi, Kayo ;
Sumimoto, Takumi ;
Okura, Takafumi ;
Higaki, Jitsuo .
HYPERTENSION RESEARCH, 2017, 40 (02) :173-180
[46]   Correlations between cardiovascular risk factors and insulin resistance in hypertensive and normotensive obese patients [J].
González-Albarrán, O ;
Roa, C ;
Fraile, J ;
Pines, P ;
Sancho, JM ;
García-Robles, R .
AMERICAN JOURNAL OF HYPERTENSION, 2004, 17 (05) :32A-32A
[47]   The Relationship Between Pediatric Nonalcoholic Fatty Liver Disease and Cardiovascular Risk Factors and Increased Risk of Atherosclerosis in Obese Children [J].
Gokce, Selim ;
Atbinici, Zehra ;
Aycan, Zehra ;
Cinar, Hasibe Gokce ;
Zorlu, Pelin .
PEDIATRIC CARDIOLOGY, 2013, 34 (02) :308-315
[48]   Hypothyroidism is not associated with increased carotid atherosclerosis when cardiovascular risk factors are accounted for in hyperlipidemic patients [J].
Chiche, Francoise ;
Jublanc, Christel ;
Coudert, Mathieu ;
Carreau, Valerie ;
Kahn, Jean-Francois ;
Bruckert, Eric .
ATHEROSCLEROSIS, 2009, 203 (01) :269-276
[49]   Importance of the Environment - Air Pollution, Noise, and Heat as Cardiovascular Risk Factors [J].
Muenzel, Thomas ;
Daiber, Andreas ;
Hahad, Omar .
AKTUELLE KARDIOLOGIE, 2023, 12 (02) :113-119
[50]   Circulating Biomarkers for Cardiovascular Disease Risk Prediction in Patients With Cardiovascular Disease [J].
Wong, Yuen-Kwun ;
Tse, Hung-Fat .
FRONTIERS IN CARDIOVASCULAR MEDICINE, 2021, 8