LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition

被引：704
|
作者：
Singh, SK
Nielsen, P
Koshkin, AA
Wengel, J
机构：
[1] Univ Copenhagen, Dept Chem, DK-2100 Copenhagen, Denmark
[2] Odense Univ, Dept Chem, DK-5230 Odense M, Denmark
来源：
CHEMICAL COMMUNICATIONS | 1998年 / 04期
关键词：
D O I：
10.1039/a708608c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel class of nucleic acid analogues, termed LNA (locked nucleic acids), is introduced. Following the Watson-Crick base pairing rules, LNA forms duplexes with complementary DNA and RNA with remarkably increased thermal stabilities and generally improved selectivities.
引用
收藏
页码：455 / 456
页数：2
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