Synthesis of 4-Arylselanyl-1H-1,2,3-triazoles from Selenium-Containing Carbinols

被引：5

作者：

Begini, Francesca ^{[1
]}

Balaguez, Renata A. ^{[2
]}

Larroza, Allya ^{[2
]}

Lopes, Eric F. ^{[2
]}

Lenardao, Eder Joao ^{[2
]}

Santi, Claudio ^{[1
]}

Alves, Diego ^{[2
]}

机构：

[1] Univ Perugia, Dept Pharmaceut Sci, Grp Catalysis Synth & Organ Green Chem, Via Liceo 1, I-06123 Perugia, Italy

[2] Univ Fed Pelotas UFPel, LASOL CCQFA, POB 354, BR-96010900 Pelotas, RS, Brazil

来源：

MOLECULES | 2021年 / 26卷 / 08期

关键词：

selenium; 1; 2; 3-triazoles; click chemistry; cycloaddition; carbinols; heterocycles; AZIDE-ALKYNE CYCLOADDITION; CLICK CHEMISTRY; 7-CHLOROQUINOLINE-1,2,3-TRIAZOYL CARBOXAMIDES; 1,3-DIPOLAR CYCLOADDITION; ORGANOCATALYTIC SYNTHESIS; TERMINAL ALKYNES; 1,2,3-TRIAZOLE; CASCADE; TOOL;

D O I：

10.3390/molecules26082224

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this work, we present a simple way to achieve 4-arylselanyl-1H-1,2,3-triazoles from selenium-containing carbinols in a one-pot strategy. The selenium-containing carbinols were used as starting materials to produce a range of selanyl-triazoles in moderate to good yields, including a quinoline and Zidovudine derivatives. One-pot protocols are crucial to the current concerns about waste production and solvent consumption, avoiding the isolation and purification steps of the reactive terminal selanylalkynes. We could also isolate an interesting and unprecedented by-product with one alkynylselenium moiety connected to the triazole.

引用

页数：11

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