Neuropathology of dementia

被引：3

作者：

Klotz, Sigrid ^{[1
,2
]}

Gelpi, Ellen ^{[1
,2
]}

机构：

[1] Univ Klin Neurol, Abt Neuropathol & Neurochem, Med Univ Campus Wien,Ebene 4J, A-1090 Vienna, Austria

[2] Usterreich Referenzzentrum Erfassung & Dokumentat, Vienna, Austria

来源：

WIENER MEDIZINISCHE WOCHENSCHRIFT | 2021年 / 171卷 / 11-12期

关键词：

Dementia; Neuropathology; Neurodegeneration; Biomarker; Proteinopathies; FRONTOTEMPORAL LOBAR DEGENERATION; PROGRESSIVE SUPRANUCLEAR PALSY; ALPHA-SYNUCLEIN PATHOLOGY; ALZHEIMERS-DISEASE; A-BETA; CLINICOPATHOLOGICAL FEATURES; NEUROFIBRILLARY TANGLES; AMYLOID ANGIOPATHY; INCLUSION DISEASE; LEWY BODIES;

D O I：

10.1007/s10354-021-00848-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Dementia is the clinical consequence of various neurological disorders with a multitude of etiologies. Precise knowledge of the underlying pathologies is essential for an accurate treatment of patients and for the development of suitable disease biomarkers. A definite diagnosis of many of the disorders, particularly for neurodegenerative ones, can only be made after a thorough postmortem neuropathological examination. This highlights the importance of performing a brain autopsy and the relevance of a close interaction between clinicians, neuroimaging disciplines and neuropathologists as well as with basic researchers. This article aims to give a brief overview on the neuropathology of dementia focusing on neurodegenerative diseases, to further facilitate interdisciplinary collaboration.

引用

页码：257 / 273

页数：17

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