Dearomatization of Electron-Deficient Nitrogen Heterocycles via Cobalt-Catalyzed Asymmetric Cyclopropanation

被引：16

作者：

Joshi-Pangu, Amruta ^{[1
]}

Cohen, Ryan D. ^{[1
]}

Tudge, Matthew T. ^{[1
]}

Chen, Yonggang ^{[1
]}

机构：

[1] Merck & Co Inc, Dept Proc & Analyt Chem, POB 2000, Rahway, NJ 07065 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 08期

关键词：

IN-SITU GENERATION; INTRAMOLECULAR CYCLOPROPANATION; CHIRAL LIGANDS; ENANTIOSELECTIVE CYCLOPROPANATION; OLEFIN CYCLOPROPANATION; CONSTRUCTION; DIAZOMETHANE; COMPLEXES; PEPTIDOMIMETICS; DIAZOACETATES;

D O I：

10.1021/acs.joc.6b00322

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The dearomatization of a series of electron-deficient nitrogen heterocycles has been achieved through a cobalt-catalyzed asymmetric cyclopropanation reaction. This reaction proceeds with high levels of enantio- and diastereoselectivity to afford unique cyclopropanes that can be further functionalized to provide complex heterocyclic building blocks.

引用

页码：3070 / 3075

页数：6

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