A base-catalyzed domino-isomerization-hydroamination reaction - A new synthetic route to amphetamines

被引：69
作者：
Hartung, CG
Breindl, C
Tillack, A
Beller, M
机构：
[1] Univ Rostock eV, IfOK, D-18055 Rostock, Germany
[2] Tech Univ Munich, Inst Anorgan Chem, D-85747 Garching, Germany
来源：
TETRAHEDRON | 2000年 / 56卷 / 29期
关键词：
domino-isomerization-amination reaction; base-catalysis; hydroamination; amphetamines;
D O I：
10.1016/S0040-4020(00)00436-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient synthesis of pharmaceutically interesting amphetamines by a base-catalyzed domino-isomerization-hydroamination reaction is presented. Starting from allylbenzene and various primary or secondary amines, the basic structural pattern of amphetamines is synthesized directly in yields of up to 91% in the presence of catalytic amounts of n-butyllithium. (C) 2000 Elsevier Science Ltd. All rights reserved.
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收藏
页码：5157 / 5162
页数：6
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