A pH sensitive fluorescent cyanine dye for biological applications

被引：100

作者：

Briggs, MS ^{[1
]}

Burns, DD ^{[1
]}

Cooper, ME ^{[1
]}

Gregory, SJ ^{[1
]}

机构：

[1] Amersham Pharmacia Biotech, Drug Discovery, Forest Farm, Cardiff CF14 7YT, S Glam, Wales

来源：

CHEMICAL COMMUNICATIONS | 2000年 / 23期

关键词：

D O I：

10.1039/b007108k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A pentamethine cyanine dye has been synthesised that is fluorescent when protonated, becoming non-fluorescent upon proton abstraction. The probe has a pK(a) of 7.5, with observable changes in the fluorescent emission properties across a pH range of 6.0-8.0, therefore providing a useful probe for studying pH in biological media.

引用

页码：2323 / 2324

页数：2

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