Plasmonic gold nanoparticles: Optical manipulation, imaging, drug delivery and therapy

被引：231

作者：

Sharifi, Majid ^{[1
,2
]}

Attar, Farnoosh ^{[3
]}

Saboury, Ali Akbar ^{[4
]}

Akhtari, Keivan ^{[5
]}

Hooshmand, Nasrin ^{[6
]}

Hasan, Anwarul ^{[7
,8
]}

El-Sayed, Mostafa A. ^{[6
]}

Falahati, Mojtaba ^{[1
]}

机构：

[1] Islamic Azad Univ, Fac Adv Sci & Technol, Dept Nanotechnol, Tehran Med Sci, Tehran, Iran

[2] Univ Tabriz, Fac Agr, Dept Anim Sci, Tabriz, Iran

[3] Stand Res Inst, Fac Food Ind & Agr, Dept Biol, Karaj, Iran

[4] Univ Tehran, Inst Biochem & Biophys, Tehran, Iran

[5] Univ Kurdistan, Dept Phys, Sanandaj, Iran

[6] Sch Chem & Biochem, Georgia Inst Technol, Laser Dynam Lab, Atlanta, GA 30332 USA

[7] Qatar Univ, Coll Engn, Dept Mech & Ind Engn, Doha 2713, Qatar

[8] Qatar Univ, Biomed Res Ctr, Doha 2713, Qatar

来源：

JOURNAL OF CONTROLLED RELEASE | 2019年 / 311卷

关键词：

Plasmonic gold nanoparticle; Optical manipulation; Photothermal therapy; Imaging; Drug delivery; SURFACE-ENHANCED RAMAN; SYNERGISTIC PHOTOTHERMAL THERAPY; CORE-SHELL NANOPARTICLES; RAY COMPUTED-TOMOGRAPHY; MESENCHYMAL STEM-CELLS; IN-VIVO TRACKING; X-RAY; CANCER-CELLS; INORGANIC NANOPARTICLES; SINGLE MOLECULES;

D O I：

10.1016/j.jconrel.2019.08.032

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Over the past two decades, the development of plasmonic nanoparticle (NPs), especially gold (Au) NPs, is being pursued more seriously in the medical fields such as imaging, drug delivery, and theranostic systems. However, there is no comprehensive review on the effect of the physical and chemical parameters of AuNPs on their plasmonic properties as well as the use of these unique characteristic in medical activities such as imaging and therapeutics. Therefore, in this literature the surface plasmon resonance (SPR) modeling of AuNPs was accurately captured toward precision medicine. Indeed, we investigated the importance of plasmonic properties of AuNPs in optical manipulation, imaging, drug delivery, and photothermal therapy (PTT) of cancerous cells based on their physicochemical properties. Finally, some challenges regarding the commercialization of AuNPs in future medicine such as, cytotoxicity, lack of standards for medical applications, high cost, and time-consuming process were discussed.

引用

页码：170 / 189

页数：20

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