Neolignans and Glycosides from the Stem Bark of Illicium difengpi

被引：53

作者：

Fang, Lei

Du, Dan

Ding, Guang-Zhi

Si, Yi-Kang

Yu, Shi-Shan ^{[1
]}

Liu, Yang

Wang, Wen-Jie

Ma, Shuang-Gang

Xu, Song

Qu, Jing

Wang, Jia-Ming

Liu, Yu-Xi

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, Key Lab Bioact Subst & Resources Utilizat Chinese, Minist Educ, Beijing 100050, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2010年 / 73卷 / 05期

关键词：

ALDER TYPE ADDUCTS; ABSOLUTE-CONFIGURATION; CHIROPTICAL PROPERTIES; CHROMOPHORES; ROOT;

D O I：

10.1021/np900712v

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five new neolignans (1-4 and 9), two pairs of neolignan epimers (5-8), and two new aromatic glycosides (10 and 11) have been isolated from the stem bark of Illicium difengpi. Their structures were determined by spectroscopic methods, including 1D and 2D NMR, HRESIMS, CD experiments, and chemical methods. The absolute configurations of the 3,4-diol moiety in 1 and 1,3-diol moiety in 2 were confirmed by Snarzke's method, observing the induced circular dichroism after addition of dimolybdenum tetraacetate in DMSO. Compounds 3, 4, and 11 exhibited moderate anti-inflammatory activities with IC50 values ranging from 1.62 to 24.4 mu M, while compound 3 displayed antioxidant activity with an IC50 value of 42.3 mu M.

引用

页码：818 / 824

页数：7

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