Mechanistic Study of the Collision-Induced Dissociation of Sodium-Cationized Polylactide Oligomers: A Joint Experimental and Theoretical Investigation

被引:25
作者
De Winter, Julien [1 ]
Lemaur, Vincent [2 ]
Marsal, Philippe [2 ,4 ]
Coulembier, Olivier [3 ]
Cornil, Jerome [2 ]
Dubois, Philippe [3 ]
Gerbaux, Pascal [1 ]
机构
[1] Univ Mons, Ctr Interdisciplinaire Spectometrie Masse, Mass Spectrometry Res Grp, B-7000 Mons, Belgium
[2] Univ Mons, Lab Chem Novel Mat, B-7000 Mons, Belgium
[3] Univ Mons, Lab Polymer & Composite Mat, Ctr Innovat & Res Mat & Polymers, B-7000 Mons, Belgium
[4] Univ Aix Marseille 2 & 3, CNRS, CINaM, Marseille, France
关键词
FORCE-FIELD; STRUCTURAL INFORMATION; MASS-SPECTROMETRY; GENERATION; LACTIDE;
D O I
10.1016/j.jasms.2010.03.026
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The low-kinetic energy collision-induced dissociation (CID) behavior of different sodium-cationized polylactide (PLA) oligomers was thoroughly investigated to shed some light on the analytical potentialities of CID experiments in the context of polymer characterization. Indeed, investigation of several end-groups modified PLA reveals that, in addition to the expected end-group specific dissociations, collisionally-excited PLA.Na+ suffer from a backbone cleavage. The so-obtained sodium-bound dimer cations consecutively undergo the loss of a monomeric residue that corresponds to neutral acrylic acid. The experimental observations, performed on a hybrid Q-ToF instrument, were totally corroborated by a theoretical study involving DFT calculations, molecular mechanics, and molecular dynamics calculations. (J Am Soc Mass Spectrom 2010, 21, 1159-1168) (C) 2010 American Society for Mass Spectrometry
引用
收藏
页码:1159 / 1168
页数:10
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