Leukocyte telomere length and risk of gastric cardia adenocarcinoma

被引：6

作者：

Liu, Yang ^{[1
,2
,3
]}

Lei, Tianshui ^{[1
,2
]}

Zhang, Nasha ^{[2
]}

Zheng, Yan ^{[2
]}

Kou, Peisi ^{[2
]}

Shang, Shuheng ^{[2
]}

Yang, Ming ^{[2
]}

机构：

[1] Univ Jinan, Sch Med & Life Sci, Shandong Acad Med Sci, Jinan, Shandong, Peoples R China

[2] Shandong Univ, Shandong Acad Med Sci, Shandong Prov Key Lab Radiat Oncol, Canc Res Ctr,Shandong Canc Hosp, Jinan, Shandong, Peoples R China

[3] Shandong Univ, Shandong Acad Med Sci, Dept Radiat Oncol, Shandong Canc Hosp, Jinan, Shandong, Peoples R China

来源：

SCIENTIFIC REPORTS | 2018年 / 8卷

基金：

中国国家自然科学基金;

关键词：

OXIDATIVE STRESS; CANCER RISK; CIGARETTE-SMOKING; GENETIC-VARIANTS; ESOPHAGEAL;

D O I：

10.1038/s41598-018-32954-6

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

As a chromosome stabilizer, telomeres play an essential part in maintaining the stability and integrity of human genome. Shortened telomeres have been associated with the development of cancers but it is still largely unclear whether leukocyte telomere length contributes to predisposition of gastric cardia adenocarcinoma (GCA). We conducted a case-control study consisting of 524 GCA cases and 510 controls to assess the association between telomere length in peripheral blood leukocytes and GCA risk in a Chinese Han population. The GCA patients had significantly overall shorter relative leukocyte telomere length (RTL) (median +/- SD: 1.10 +/- 0.54) when compared with the controls (1.24 +/- 0.58). Individuals with the shortest quartile of RTL performed a doubled GCA risk (OR = 2.18; 95% CI = 1.47-3.22, P= 9.90 x 10(-5)) when compared with those with the highest quartile. We also found that telomere shortening and smoking have a significantly synergistic effect in intensifying risk of GCA (OR = 7.03, 95% CI = 4.55-10.86, P = 1.43 x 10(-18)). These findings indicate that short RTL contributes to increased susceptibility of gastric cardia adenocarcinoma and might be a promising marker to identify high-risk individuals combined with lifestyle risk factors.

引用

页数：6