Silica-based nanosystems for therapeutic applications in the skin

被引：18

作者：

Arriagada, Francisco ^{[1
]}

Nonell, Santi ^{[2
]}

Morales, Javier ^{[1
]}

机构：

[1] Univ Chile, Fac Ciencias Quim & Farmaceut, Dept Ciencias & Tecnol Farmaceut, Santiago 8380494, Chile

[2] Univ Ramon Llull, IQS, Via Augusta 390, Barcelona 08017, Spain

来源：

NANOMEDICINE | 2019年 / 14卷 / 16期

关键词：

cancer; nanomedicine; photodynamic therapy; photoprotection; silica nanoparticles; silica nanosystems; skin; skin disorders; topical delivery; wound healing; LIPOSOME-ENCAPSULATED CURCUMIN; FILM-FORMING FORMULATIONS; MESOPOROUS SILICA; DRUG-DELIVERY; IN-VITRO; ULTRAVIOLET-RADIATION; PHOTODYNAMIC THERAPY; TOPICAL APPLICATION; TARGETED DELIVERY; CONTROLLED GROWTH;

D O I：

10.2217/nnm-2019-0052

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aging, exposure to oxidants, infectious pathogens, inflammogens, ultraviolet radiation and other environmental and genetic factors can result in the development of various skin disorders. Despite immense progress being made in dermatological treatments, many skin-associated problems still remain difficult to treat and various therapies have limitations. Progress in silica-based nanomaterials research provides an opportunity to overcome these drawbacks and improve therapies and is a promising tool for inclusion in clinical practice to treat skin diseases. This review focuses on the use of various types of silica nanoparticles with therapeutic applications in various skin disorders. These nanosystems improve treatment efficacy by maintaining or enhancing the effect of several drugs and are useful tools for nanomedicine, pharmaceutical sciences and future clinical applications.

引用

页码：2243 / 2267

页数：25