Growth hormone signalling mechanisms: Involvement of the tyrosine kinase JAK2

被引：33
作者：
Argetsinger, LS
CarterSu, C
机构：
[1] Department of Physiology, University of Michigan Medical School, Ann Arbor, MI
来源：
HORMONE RESEARCH | 1996年 / 45卷
关键词：
growth hormone; insulin receptor substrate-1; JAK2; MAP kinase; STAT;
D O I：
10.1159/000184823
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Demonstration that the tyrosine kinase JAK2 is activated in response to growth hormone (GH) has established tyrosyl phosphorylation as a signalling mechanism for GH, In addition a number of signalling molecules have recently been identified that interact with the GH receptor/JAK2 complex and require JAK2 for activation. These pathways regulate cellular functions including gene transcription, metabolite transport, and metabolism and contribute to the ability of GH to control body growth and metabolism.
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页码：22 / 24
页数：3
相关论文
共 19 条
  • [1] GROWTH-HORMONE, INTERFERON-GAMMA, AND LEUKEMIA INHIBITORY FACTOR PROMOTED TYROSYL PHOSPHORYLATION OF INSULIN-RECEPTOR SUBSTRATE-1
    ARGETSINGER, LS
    HSU, GW
    MYERS, MG
    BILLESTRUP, N
    WHITE, MF
    CARTERSU, C
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (24) : 14685 - 14692
  • [2] IDENTIFICATION OF JAK2 AS A GROWTH-HORMONE RECEPTOR-ASSOCIATED TYROSINE KINASE
    ARGETSINGER, LS
    CAMPBELL, GS
    YANG, XN
    WITTHUHN, BA
    SILVENNOINEN, O
    IHLE, JN
    CARTERSU, C
    [J]. CELL, 1993, 74 (02) : 237 - 244
  • [3] ARGETSINGER LS, 1996, IN PRESS PHYSL REV, V76
  • [4] CAMPBELL GS, 1992, J BIOL CHEM, V267, P6074
  • [5] ACTIVATION OF ACUTE-PHASE RESPONSE FACTOR (APRF)/STAT3 TRANSCRIPTION FACTOR BY GROWTH-HORMONE
    CAMPBELL, GS
    MEYER, DJ
    RAZ, R
    LEVY, DE
    SCHWARTZ, J
    CARTERSU, C
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (08) : 3974 - 3979
  • [6] PHOSPHATIDYLINOSITOL 3-KINASE ACTIVATION IS REQUIRED FOR INSULIN STIMULATION OF PP70 S6 KINASE, DNA-SYNTHESIS, AND GLUCOSE-TRANSPORTER TRANSLOCATION
    CHEATHAM, B
    VLAHOS, CJ
    CHEATHAM, L
    WANG, L
    BLENIS, J
    KAHN, CR
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (07) : 4902 - 4911
  • [7] HUMAN GROWTH-HORMONE AND HUMAN AGING
    CORPAS, E
    HARMAN, SM
    BLACKMAN, MR
    [J]. ENDOCRINE REVIEWS, 1993, 14 (01) : 20 - 39
  • [8] EFFECT OF GROWTH-HORMONE ON CARBOHYDRATE AND LIPID-METABOLISM
    DAVIDSON, MB
    [J]. ENDOCRINE REVIEWS, 1987, 8 (02) : 115 - 131
  • [9] REQUIREMENT OF TYROSINE-RESIDUE-333 AND TYROSINE-RESIDUE-338 OF THE GROWTH-HORMONE (GH) RECEPTOR FOR SELECTED GH-STIMULATED FUNCTION
    LOBIE, PE
    ALLEVATO, G
    NIELSEN, JH
    NORSTEDT, G
    BILLESTRUP, N
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (37) : 21745 - 21750
  • [10] MEYER DJ, 1994, J BIOL CHEM, V269, P4701
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