Assessing antibiotic therapy effectiveness against the major bacterial pathogens in a hospital using an integrated index

被引：6

作者：

Chen, Yong ^{[1
]}

Song, Boqiang ^{[2
,3
]}

Shan, Xue ^{[4
]}

Qin, Yanhong ^{[5
]}

Wang, Liang ^{[4
]}

Wang, Hongyuan ^{[4
]}

Lu, Zhongyi ^{[1
]}

Liu, Lin ^{[1
]}

Yin, Danping ^{[6
]}

Han, Xuelin ^{[1
]}

Zhao, Jingya ^{[1
]}

Tian, Shuguang ^{[1
]}

Chen, Fangyan ^{[1
]}

Su, Xueting ^{[1
]}

Huang, Liuyu ^{[1
]}

Li, Qi ^{[2
]}

Grundmann, Hajo ^{[7
]}

Zhang, Hong ^{[5
]}

Han, Li ^{[1
]}

机构：

[1] Acad Mil Med Sci, Inst Dis Control & Prevent, Ctr Hosp Infect Control, Beijing 100071, Peoples R China

[2] Peking Univ, SESS, Beijing 100871, Peoples R China

[3] Beijing Adv Innovat Ctr Future Internet Technol, Geospatial Big Data Team, Beijing 100124, Peoples R China

[4] Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 1000191, Peoples R China

[5] Acad Mil Med Sci, Affiliated Hosp, Dept Resp & Crit Care Dis, Beijing 100071, Peoples R China

[6] Gen Hosp Jinan Mil Command, Dept Hosp Infect Control, Jinan 250031, Shandong, Peoples R China

[7] Univ Groningen, Univ Med Ctr Groningen, Dept Med Microbiol, NL-9700 Groningen, Netherlands

来源：

FUTURE MICROBIOLOGY | 2017年 / 12卷 / 10期

基金：

北京市自然科学基金;

关键词：

antimicrobial resistance; drug resistance index; inadequate antibiotic treatment; infection control; nosocomial infection; ANTIMICROBIAL RESISTANCE; HEALTH; APPROPRIATENESS; EPIDEMIOLOGY;

D O I：

10.2217/fmb-2017-0025

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

To assess the effectiveness of antibiotic therapy against five indicator bacteria in a Chinese hospital using an index-based approach. Methods: The study population comprises 1031 patients who had one clinically significant bacterial isolate in 2008, 2010 and 2013. Drug resistance index (DRI) based on pathogens was calculated. Results: The adaptive DRIs for Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus decreased, while both adaptive and fixed DRIs for Acinetobacter spp. increased from 2008 to 2013. The adaptive DRIs for Escherichia coli increased from 2008 to 2013, while the fixed DRIs exhibited a decreasing trend. Conclusion: DRI could be used to demonstrate the changes of antimicrobial resistance and prescribing over time as a result of evolutionary processes and governmental regulatory interference.

引用

页码：853 / 866

页数：14

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