A Structures for Lossless Ion Manipulations (SLIM) Module for Collision Induced Dissociation

被引：17
|
作者：
Webb, Ian K.
Garimella, Sandilya V. B.
Norheim, Randolph V.
Baker, Erin S.
Ibrahim, Yehia M.
Smith, Richard D. [1 ]
机构：
[1] Pacific NW Natl Lab, Div Biol Sci, 3335 Innovat Ave K8-98,POB 999, Richland, WA 99352 USA
来源：
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY | 2016年 / 27卷 / 07期
基金：
美国国家卫生研究院;
关键词：
Collision induced dissociation; Ion mobility spectrometry; rf Confinement; Ion optics; Peptide fragmentation; Manipulation; Conveyor; SURFACE-INDUCED DISSOCIATION; FLIGHT MASS-SPECTROMETER; FUNNEL TRAP; MOBILITY SPECTROMETRY; FRAGMENTATION; OPTIMIZATION; SEPARATION; INTERFACE; PEPTIDES;
D O I：
10.1007/s13361-016-1397-x
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A collision induced dissociation (CID) structure for lossless ion manipulations (SLIM) module is introduced and coupled to a quadrupole time-of-flight (QTOF) mass spectrometer. The SLIM CID module was mounted after an ion mobility (IM) drift tube to enable IM/CID/MS studies. The efficiency of CID was studied by using the model peptide leucine enkephalin. CID efficiencies (62%) compared favorably with other beam-type CID methods. Additionally, the SLIM CID module was used to fragment a mixture of nine peptides after IM separation. This work also represents the first application of SLIM in the 0.3 to 0.5 Torr pressure regime, an order of magnitude lower in pressure than previously studied.
引用
收藏
页码：1285 / 1288
页数：4
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