A Structures for Lossless Ion Manipulations (SLIM) Module for Collision Induced Dissociation

被引：17
|
作者：
Webb, Ian K.
Garimella, Sandilya V. B.
Norheim, Randolph V.
Baker, Erin S.
Ibrahim, Yehia M.
Smith, Richard D. [1 ]
机构：
[1] Pacific NW Natl Lab, Div Biol Sci, 3335 Innovat Ave K8-98,POB 999, Richland, WA 99352 USA
来源：
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY | 2016年 / 27卷 / 07期
基金：
美国国家卫生研究院;
关键词：
Collision induced dissociation; Ion mobility spectrometry; rf Confinement; Ion optics; Peptide fragmentation; Manipulation; Conveyor; SURFACE-INDUCED DISSOCIATION; FLIGHT MASS-SPECTROMETER; FUNNEL TRAP; MOBILITY SPECTROMETRY; FRAGMENTATION; OPTIMIZATION; SEPARATION; INTERFACE; PEPTIDES;
D O I：
10.1007/s13361-016-1397-x
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A collision induced dissociation (CID) structure for lossless ion manipulations (SLIM) module is introduced and coupled to a quadrupole time-of-flight (QTOF) mass spectrometer. The SLIM CID module was mounted after an ion mobility (IM) drift tube to enable IM/CID/MS studies. The efficiency of CID was studied by using the model peptide leucine enkephalin. CID efficiencies (62%) compared favorably with other beam-type CID methods. Additionally, the SLIM CID module was used to fragment a mixture of nine peptides after IM separation. This work also represents the first application of SLIM in the 0.3 to 0.5 Torr pressure regime, an order of magnitude lower in pressure than previously studied.
引用
收藏
页码：1285 / 1288
页数：4
相关论文
共 50 条
  • [21] Mobility-Selected Ion Trapping and Enrichment Using Structures for Lossless Ion Manipulations
    Chen, Tsung-Chi
    Ibrahim, Yehia M.
    Webb, Ian K.
    Garimella, Sandilya V. B.
    Zhang, Xing
    Hamid, Ahmed M.
    Deng, Liulin
    Karnesky, William E.
    Prost, Spencer A.
    Sandoval, Jeremy A.
    Norheim, Randolph V.
    Anderson, Gordon A.
    Tolmachev, Aleksey V.
    Baker, Erin S.
    Smith, Richard D.
    ANALYTICAL CHEMISTRY, 2016, 88 (03) : 1728 - 1733
  • [22] Masked Multiplexed Separations to Enhance Duty Cycle for Structures for Lossless Ion Manipulations
    Clowers, Brian H.
    Cabrera, Elvin
    Anderson, Gordon
    Deng, Liulin
    Moser, Kelly
    Van Aken, Gregory
    DeBord, John Daniel
    ANALYTICAL CHEMISTRY, 2021, 93 (14) : 5727 - 5734
  • [23] Analysis of Native-Like Ions Using Structures for Lossless Ion Manipulations
    Allen, Samuel J.
    Eaton, Rachel M.
    Bush, Matthew F.
    ANALYTICAL CHEMISTRY, 2016, 88 (18) : 9118 - 9126
  • [24] Evaluation of Waveform Profiles for Traveling Wave Ion Mobility Separations in Structures for Lossless Ion Manipulations
    Conant, Christopher R.
    Attah, Isaac K.
    Garimella, Sandilya V. B.
    Nagy, Gabe
    Bilbao, Aivett
    Smith, Richard D.
    Ibrahim, Yehia M.
    JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2021, 32 (01) : 225 - 236
  • [25] New frontiers for mass spectrometry based upon structures for lossless ion manipulations
    Ibrahim, Yehia M.
    Hamid, Ahmed M.
    Deng, Liulin
    Garimella, Sandilya V. B.
    Webb, Ian K.
    Baker, Erin S.
    Smith, Richard D.
    ANALYST, 2017, 142 (07) : 1010 - 1021
  • [26] Structures and dissociation of iron porphyrin complexes by ion mobility and collision-induced dissociation mass spectrometry
    Gholami, Ameneh
    Hampe, Oliver
    Mayer, Paul M.
    CANADIAN JOURNAL OF CHEMISTRY, 2023, 101 (04) : 260 - 273
  • [27] Evaluation of Waveform Profiles for Traveling Wave Ion Mobility Separations in Structures for Lossless Ion Manipulations
    Smith, Richard D. (rds@pnnl.gov); Ibrahim, Yehia M. (Yehia.ibrahim@pnnl.gov), 1600, American Chemical Society (32):
  • [28] Compression Ratio Ion Mobility Programming (CRIMP) Accumulation and Compression of Billions of Ions for Ion Mobility-Mass Spectrometry Using Traveling Waves in Structures for Lossless Ion Manipulations (SLIM)
    Deng, Liulin
    Garimella, Sandilya V. B.
    Hamid, Ahmed M.
    Webb, Ian K.
    Attah, Isaac K.
    Norheim, Randolph V.
    Prost, Spencer A.
    Zheng, Xueyun
    Sandoval, Jeremy A.
    Baker, Erin S.
    Ibrahim, Yehia M.
    Smith, Richard D.
    ANALYTICAL CHEMISTRY, 2017, 89 (12) : 6432 - 6439
  • [29] Traveling-Wave-Based Electrodynamic Switch for Concurrent Dual-Polarity Ion Manipulations in Structures for Lossless Ion Manipulations
    Attah, Isaac K.
    Nagy, Gabe
    Garimella, Sandilya V. B.
    Norheim, Randolph V.
    Anderson, Gordon A.
    Ibrahim, Yehia M.
    Smith, Richard D.
    ANALYTICAL CHEMISTRY, 2019, 91 (22) : 14712 - 14718
  • [30] A Hybrid Constant and Oscillatory Field Ion Mobility Analyzer Using Structures for Lossless Ion Manipulations
    Prabhakaran, Aneesh
    Hamid, Ahmed M.
    Garimella, Sandilya V. B.
    Valenzuela, Blandina R.
    Ewing, Robert G.
    Ibrahim, Yehia M.
    Smith, Richard D.
    JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2018, 29 (02) : 342 - 351
12345