A Short and Efficient Total Synthesis of (±)-Ascofuranone

被引：6

作者：

Haga, Yasushi ^{[1
]}

Tonoi, Takayuki ^{[2
]}

Anbiru, Yoshihide ^{[1
]}

Takahashi, Yuki ^{[1
]}

Tamura, Sayuri ^{[1
]}

Yamamoto, Masaichi ^{[3
]}

Ifuku, Shinsuke ^{[1
]}

Morimoto, Minoru ^{[2
]}

Saimoto, Hiroyuki ^{[1
]}

机构：

[1] Tottori Univ, Grad Sch Engn, Dept Chem & Biotechnol, Tottori 6808552, Japan

[2] Tottori Univ, Res Ctr Biosci & Technol, Tottori 6808552, Japan

[3] ARigen Pharmaceut Inc, Minato Ku, Tokyo 1070052, Japan

来源：

CHEMISTRY LETTERS | 2010年 / 39卷 / 06期

关键词：

2-BUTYNE-1,4-DIOL DERIVATIVES; MICROBIAL CHEMISTRY; ASCOFURANONE; 4,5-DIHYDRO-3(2H)-FURANONES; TRANSFORMATION; GEIPARVARIN; BULLATENONE; ANTITUMOR; PROPERTY;

D O I：

10.1246/cl.2010.622

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ascofuranone is a potent inhibitor of trypanosome alternative oxidase. A short and efficient total synthesis of (+/-)-ascoffiranone was accomplished in only seven steps starting with geranyl acetate. The synthetic concept and methodology described in detail here provide a short and simple synthesis for ascofuranone and its derivatives.

引用

页码：622 / 623

页数：2

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