Synthesis of some new 2,4-disubstituted thiazoles as possible antibacterial and driti-inflammatory agents

被引：295

作者：

Holla, BS ^{[1
]}

Malini, KV

Rao, BS

Sarojini, BK

Kumari, NS

机构：

[1] Mangalore Univ, Dept Postgrad Studies & Res Chem, Mangalagangothri 574199, India

[2] KS Hegde Med Acad, Dept Biochem, Deralakatte, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2003年 / 38卷 / 03期

关键词：

thiazoles; arylthiourea; arylaldehydethiosemicarbazone; arylfurfuraldehyde thiosemicarbazone; antibacterial activity; anti-inflammatory activity;

D O I：

10.1016/S0223-5234(02)01447-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of arylthioureas (1), aromatic aldehyde thiosemicarbazones (2) and 5-aryl-2-furfuraldehyde thiosemicarbazones (3) were condensed with 2,4-dichloro-5-fluorophenacyl bromide to yield respective arylaminothiazoles, arylidene/5-aryl-2-furfurylidene hydrazinothiazoles (4). The newly synthesized compounds were characterized by IR, H-1-NMR and mass spectral studies. These compounds were also screened for their antibacterial and anti-inflammatory activities. Two of the newly synthesized compounds showed anti-inflammatory activity comparable with that of Ibuprofen. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

页码：313 / 318

页数：6

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