Copper-Catalyzed Selective 1,2-Dialkylation of N-Heteroarenes via a Radical Addition/Reduction Process: Application for the Construction of Alkylated Dihydroazaarenes Derivatives

被引：20
作者：
Sun, Qu [1 ]
Zhang, Yuan-Yuan [1 ]
Sun, Jing [1 ]
Han, Ying [1 ]
Jia, Xiaodong [1 ]
Yan, Chao-Guo [1 ]
机构：
[1] Yangzhou Univ, Coll Chem & Chem Engn, Yangzhou 225002, Jiangsu, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 12期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
C-H FUNCTIONALIZATION; BIOMIMETIC ASYMMETRIC HYDROGENATION; BOND ACTIVATION; HETEROAROMATIC BASES; COUPLING REACTIONS; ALPHA-ARYLATION; VISIBLE-LIGHT; HETEROCYCLES; METAL; PYRIDINES;
D O I：
10.1021/acs.joc.8b00928
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly efficient Cu-catalyzed 1,2-difunctionalization of various N-heteroarenes was developed with ether and alkyl halide at ambient temperature. This transformation involves the combination of oxidative coupling by Cu/TBHP and reduction process by 1,8-diazabicyclo[5.4.0]undec-7-ene. This method provides an efficient method to prepare various substituted dihydroazaarene derivatives via a free-radical process.
引用
收藏
页码：6640 / 6649
页数：10
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