A Time-Resolved Single-Molecular Train Based on Aerolysin Nanopore

被引：33
|
作者：
Ying, Yi-Lun [1 ,2 ]
Li, Zi-Yuan [1 ,2 ]
Hu, Zheng-Li [1 ,2 ]
Zhang, Junji [1 ,2 ]
Meng, Fu-Na [1 ,2 ]
Cao, Chan [1 ,2 ]
Long, Yi-Tao [1 ,2 ]
Tian, He [1 ,2 ]
机构：
[1] East China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China
[2] East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China
来源：
CHEM | 2018年 / 4卷 / 08期
基金：
中国国家自然科学基金;
关键词：
PROTEIN TRANSLOCATION; MEMBRANE-CHANNEL; ALPHA-HEMOLYSIN; DNA; MACHINES; MOTION; PHOTOISOMERIZATION; DISCRIMINATION; AZOBENZENE; MECHANISM;
D O I：
10.1016/j.chempr.2018.05.004
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An aerolysin nanopore interface was introduced as a molecular machine to electrically read out the real-time photo-controlled motion of an azobenzene-geared DNA train with high spatial and temporal resolution. Under alternating UV and visible irradiation, each DNA train performed two regulated speeds of 1.9 and 6.3 bases/s corresponding to trans and cis states, respectively, with readily identified current signals. Each train type fell into the ultra-narrow current population with a full-width half maximum of 0.2-0.4 pA. The combination of a model molecular machine system and powerful aerolysin interface enabled the motions of every artificial molecular machine to be followed in real time.
引用
收藏
页码：1893 / 1901
页数：9
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