Type 2 diabetes: When insulin secretion fails to compensate for insulin resistance

被引：355

作者：

Kahn, BB ^{[1
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Dept Med, Diabet Unit, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Boston, MA 02215 USA

来源：

CELL | 1998年 / 92卷 / 05期

关键词：

D O I：

10.1016/S0092-8674(00)81125-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：593 / 596

页数：4

共 20 条

[1] Insulin receptor knock-out mice [J].

Accili, D .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 1997, 8 (03) :101-104

[2] ALTERNATIVE PATHWAY OF INSULIN SIGNALING IN MICE WITH TARGETED DISRUPTION OF THE IRS-1 GENE [J].

ARAKI, E ;

LIPES, MA ;

PATTI, ME ;

BRUNING, JC ;

HAAG, B ;

JOHNSON, RS ;

KAHN, CR .

NATURE, 1994, 372 (6502) :186-190

[3]

BERNAL D, 1998, IN PRESS DIABETES

[4] Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles [J].

Bruning, JC ;

Winnay, J ;

BonnerWeir, S ;

Taylor, SI ;

Accili, D ;

Kahn, CR .

CELL, 1997, 88 (04) :561-572

[5] OBESE AND DIABETES - 2 MUTANT-GENES CAUSING DIABETES-OBESITY SYNDROMES IN MICE [J].

COLEMAN, DL .

DIABETOLOGIA, 1978, 14 (03) :141-148

[6]

DeFronzo RA, 1997, DIABETES REV, V5, P177

[7] From receptor to transporter: insulin signalling to glucose transport [J].

Holman, GD ;

Kasuga, M .

DIABETOLOGIA, 1997, 40 (09) :991-1003

[8] Overexpression of Ha-ras selectively in adipose tissue of transgenic mice - Evidence for enhanced sensitivity to insulin [J].

Houseknecht, KL ;

Zhu, AX ;

Gnudi, L ;

Hamann, A ;

Zierath, JR ;

Tozzo, E ;

Flier, JS ;

Kahn, BB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (19) :11347-11355

[9]

Kahn CR, 1996, ANNU REV MED, V47, P509

[10] The metabolic consequences of altered glucose transporter expression in transgenic mice [J].

Katz, EB ;

Burcelin, R ;

Tsao, TS ;

Stenbit, AE ;

Charron, MJ .

JOURNAL OF MOLECULAR MEDICINE-JMM, 1996, 74 (11) :639-652

← 1 2 →