Dynamic changes in the cortico-subcortical network during early motor learning

被引:30
|
作者
Park, Ji-Won [2 ]
Kim, Yun-Hee [1 ]
Jang, Sung Ho [3 ]
Chang, Won Hyuk [1 ]
Park, Chang-Hyun [4 ]
Kim, Sung Tae [5 ]
机构
[1] Sungkyunkwan Univ, Sch Med, Dept Phys Med & Rehabil,Samsung Med Ctr, Div Neurorehabil,Stroke & Cerebrovasc Ctr, Seoul 135710, South Korea
[2] Catholic Univ Daegu, Dept Phys Therapy, Taegu, South Korea
[3] Yeungnam Univ, Sch Med, Taegu, South Korea
[4] Korea Adv Inst Sci & Technol, Dept Phys Med & Rehabil, Samsung Med Ctr, Dept Phys, Taejon 305701, South Korea
[5] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Radiol,Ctr Imaging Sci, Seoul 135710, South Korea
关键词
Cortico-subcortical network; functional MRI; motor learning; POSITRON-EMISSION-TOMOGRAPHY; TRANSCRANIAL MAGNETIC STIMULATION; BRAIN ACTIVATION; VISUOMOTOR SEQUENCE; FUNCTIONAL-ANATOMY; SKILL ACQUISITION; PREMOTOR CORTEX; FRONTAL LOBES; CEREBELLUM; MOVEMENT;
D O I
10.3233/NRE-2010-0540
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Failure of early motor learning due to damage in any brain area involved in this process may interfere with successful rehabilitation of such patients. Objective: We investigated the changes in activation of the motor network during sequential finger motor learning to delineate the characteristics of the cortico-subcortical network during motor skill learning. Methods: Twenty healthy, right-handed volunteers participated. Subjects were instructed to perform eight blocks of a sequential finger motor task while functional MRI (fMRI) was performed. Results: The participants had an improvement in performance over time from block 1 to block 4, indicating that successful learning had occurred, followed by a plateau from block 5 to the last block. On fMRI, activities of the contralateral primary sensorimotor cortex, the premotor cortex, the supplementary motor area, and the posterior parietal cortex gradually increased from block 1 to block 4 and then decreased from block 5 to the last. In contrast, activity of the ipsilateral cerebellum showed a linear increase spanning the last block with peak activation. The thalamus and basal ganglia showed unilateral or bilateral activities at the unique stage of motor learning. Conclusions: These findings delineated the characteristic plastic changes and different roles of the cortico-subcortical network during the early phase of motor learning and automatization.
引用
收藏
页码:95 / 103
页数:9
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