Theranostic and prognostic biomarkers: genomic applications in urological malignancies

被引：34
作者：
Netto, George J.
Epstein, Jonathan I.
机构：
[1] Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA
[2] Johns Hopkins Med Inst, Dept Urol, Baltimore, MD 21205 USA
[3] Johns Hopkins Med Inst, Dept Oncol, Baltimore, MD 21205 USA
来源：
PATHOLOGY | 2010年 / 42卷 / 04期
关键词：
Theranostics; urological; molecular diagnostics; prognostics; prostate; renal; urothelial; RENAL-CELL CARCINOMA; INVASIVE BLADDER-CANCER; IN-SITU HYBRIDIZATION; P53 NUCLEAR OVEREXPRESSION; PROSTATE-SPECIFIC ANTIGEN; CPG ISLAND HYPERMETHYLATION; DISEASE-SPECIFIC SURVIVAL; TMPRSS2-ERG GENE FUSION; CARBONIC-ANHYDRASE-IX; MICROVESSEL DENSITY;
D O I：
10.3109/00313021003779145
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Compared to other solid tumours such as breast, colon, and lung, the current clinical management of urological malignancies is lagging behind in terms of utilisation of clinically robust molecular tests that can identify patients that are more likely to respond to a given targeted agent, or even those in need of a more aggressive treatment approach based on well-validated molecular prognosticators. Several promising biomarkers for detection, prognosis, and targeted therapeutics are now under evaluation. The following review discusses some of the candidate biomarkers that may soon make their transition into clinically applicable assays in urological oncology patients.</.
引用
收藏
页码：384 / 394
页数：11
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