Synthesis and preliminary biological evaluation of 4,6-disubstituted 3-cyanopyridin-2(1H)-ones, a new class of calcium entry blockers

被引：8

作者：

Manna, F

Chimenti, F

Bolasco, A

Bizzarri, B

Botta, M

Tafi, A

Filippelli, A

Rossi, S

机构：

[1] Univ Rome La Sapienza, Dipartimento Studi Chim & Tecnol Sostanze Biologi, I-00185 Rome, Italy

[2] Univ Siena, Dipartimento Farmaco Chim Tecnol, I-53100 Siena, Italy

[3] Univ Naples 2, Fac Med & Chirurg, Ist Farmacol & Tossicol, I-80138 Naples, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 16期

关键词：

D O I：

10.1016/S0960-894X(00)00361-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The preparation of 3-cyano-4,6-diaryl-pyridin-2(1H)-ones 4a . h, calcium entry blockers related to diltiazem, is described starting from 1,3-diaryl-2-propen-1-ones 5. On preliminary pharmacological tests all compounds are active and some of them show calcium antagonistic activity superior or comparable to diltiazem. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1883 / 1885

页数：3

共 17 条

[1] SUBSTITUTED 1,2,3,4-TETRAHYDROAMINONAPHTHOLS - ANTIHYPERTENSIVE AGENTS, CALCIUM-CHANNEL BLOCKERS, AND ADRENERGIC-RECEPTOR BLOCKERS WITH CATECHOLAMINE-DEPLETING EFFECTS [J].