Effects of Antibiotics on Gut Microbiota

被引：445

作者：

Lange, Kathleen ^{[1
]}

Buerger, Martin ^{[1
]}

Stallmach, Andreas ^{[1
,2
]}

Bruns, Tony ^{[1
,2
]}

机构：

[1] Jena Univ Hosp, Dept Internal Med Gastroenterol Hepatol & Infect, Jena, Germany

[2] Jena Univ Hosp, Integrated Res & Treatment Ctr Sepsis Control & C, Jena, Germany

来源：

DIGESTIVE DISEASES | 2016年 / 34卷 / 03期

关键词：

Gut microbiota; Microbiome; Antibiotic therapy; Dysbiosis; Inflammatory bowel disease; PRIMARY SCLEROSING CHOLANGITIS; COLON-CANCER RISK; INTESTINAL MICROBIOTA; CROHNS-DISEASE; COLONIZATION RESISTANCE; ULCERATIVE-COLITIS; HEALTHY-VOLUNTEERS; ESCHERICHIA-COLI; DIGESTIVE-TRACT; METRONIDAZOLE;

D O I：

10.1159/000443360

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The gut microbiota influences essential human functions including digestion, energy metabolism, and inflammation by modulating multiple endocrine, neural, and immune pathways of the host. Its composition and complexity varies markedly across individuals and across different sites of the gut, but provides a certain level of resilience against external perturbation. Short-term antibiotic treatment is able to shift the gut microbiota to long-term alternative dysbiotic states, which may promote the development and aggravation of disease. Common features of post-antibiotic dysbiosis include a loss of taxonomic and functional diversity combined with reduced colonization resistance against invading pathogens, which harbors the danger of antimicrobial resistance. This review summarizes the antibiotic-related changes of the gut microbiota and potential consequences in health and disease. (C) 2016 S. Ka rger AG, Basel

引用

页码：260 / 268

页数：9

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