Synthesis, Self-Assembly, and Drug-Loading Capacity of Well-Defined Cyclodextrin-Centered Drug-Conjugated Amphiphilic A14B7 Miktoarm Star Copolymers Based on Poly(ε-caprolactone) and Poly(ethylene glycol)

被引：141

作者：

Gou, Peng-Fei ^{[1
]}

Zhu, Wei-Pu ^{[1
]}

Shen, Zhi-Quan ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Polymer Sci & Engn, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Peoples R China

来源：

BIOMACROMOLECULES | 2010年 / 11卷 / 04期

关键词：

RING-OPENING POLYMERIZATION; CLICK CHEMISTRY; BLOCK-COPOLYMERS; ENZYMATIC BIODEGRADATION; RADICAL POLYMERIZATION; TRANSFECTION REAGENTS; DIBLOCK COPOLYMER; TARGETED DELIVERY; MICELLES; OXIDE);

D O I：

10.1021/bm901371p

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Novel drug-conjugated amphiphilic A(14)B(7) miktoarm star copolymers composed of 14 poly(E-caprolactone) (PCL) arms and 7 poly(ethylene glycol) (PEG) arms with beta-cyclodextrin (beta-CD) as core moiety were synthesized by the combination of controlled ring-opening polymerization (CROP) and "click" chemistry. H-1 NMR, FT-IR, and SEC-MALLS analyses confirmed the well-defined A(14)B(7) miktoarm star architecture. These amphiphilic miktoarm star copolymers could self-assemble into multimorphological aggregates in aqueous solution, which were characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM). Moreover, the drug-loading efficiency and drug-encapsulation efficiency of the drug-conjugated miktoarm star copolymers were higher than those of the corresponding non-drug-conjugated miktoarm star copolymers.

引用

页码：934 / 943

页数：10

共 66 条

[1] Polycaprolactone-b-poly(ethylene oxide) block copolymer micelles as a novel drug delivery vehicle for neurotrophic agents FK506 and L-685,818 [J].