Stanniocalcin in terminally differentiated mammalian cells

被引:24
|
作者
Serlachius, M
Zhang, KZ
Andersson, LC
机构
[1] Univ Helsinki, Haartman Inst, Dept Pathol, FIN-00014 Helsinki, Finland
[2] Univ Helsinki, Cent Hosp, Huslab, Helsinki, Finland
关键词
stanniocalcin; terminal differentiation; survival factor; neurons; megakaryocytes; adipocytes;
D O I
10.1016/j.peptides.2004.03.031
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Stanniocalcin (STC) is a glycoprotein hormone originally found in teleost fish, where it regulates the calcium/phosphate homeostasis, and protects the fish against toxic hypercalcemia. STC was considered an exclusive fish protein, until the cloning of cDNA for human (in 1995) and murine (in 1996) STC. We originally reported a high constitutive content of STC in mammalian brain neurons, and found that the expression of STC occurred concomitantly with terminal differentiation of neural cells. Since then, we have investigated the expression of STC in relation to terminal cell differentiation also in mammalian hematopoietic tissue, and fat tissues. In this review we summarize our findings on STC expression during postmitotic differentiation in three different cell systems; in neural cells, in megakaryocytes and in adipocytes. We also present findings, suggesting that STC plays a role for maintaining the integrity of terminally differentiated mammalian cells. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码:1657 / 1662
页数:6
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