Is HIV-associated tuberculosis a risk factor for the development of cryptococcal disease?

被引：23

作者：

Jarvis, Joseph N. ^{[1
,2
,3
,4
]}

Harrison, Thomas S. ^{[2
]}

Corbett, Elizabeth L. ^{[5
,6
]}

Wood, Robin

Lawn, Stephen D. ^{[5
]}

机构：

[1] Univ Cape Town, Fac Hlth Sci, Inst Infect Dis & Mol Med, Desmond Tutu HIV Ctr, ZA-7925 Cape Town, South Africa

[2] Univ London, Dept Cellular & Mol Med, London, England

[3] GF Jooste Hosp, Infect Dis Res Unit, Cape Town, South Africa

[4] Univ Cape Town, Dept Med, Div Infect Dis, ZA-7925 Cape Town, South Africa

[5] London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1, England

[6] Trust Clin Res Programme, Blantyre, Malawi

来源：

AIDS | 2010年 / 24卷 / 04期

基金：

美国国家卫生研究院; 英国惠康基金;

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; ANTIRETROVIRAL TREATMENT PROGRAM; SOUTH-AFRICAN MINERS; SUB-SAHARAN AFRICA; PULMONARY TUBERCULOSIS; NEOFORMANS INFECTION; EARLY MORTALITY; MENINGITIS; IMPACT; PATHOGENESIS;

D O I：

10.1097/QAD.0b013e32833547f7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cryptococcal meningitis and tuberculosis are leading causes of mortality in patients initiating antiretroviral therapy in Africa. We hypothesized that a history of tuberculosis may predispose to the development of cryptococcal meningitis and examined the association using multivariate logistic regression in a cohort of patients initiating antiretroviral therapy. History of pulmonary tuberculosis was independently associated with the development of cryptococcal meningitis ( odds ratio = 6.6; 95% confidence interval = 1.3-32.7) after adjustment for covariates, including CD4 cell counts. A number of potential mechanisms may underlie this association.

引用

页码：612 / 614

页数：3

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