Tuning the regulator: Phosphorylation of KCC2 at two specific sites is critical for neurodevelopment

被引：3

作者：

Zamponi, Gerald W. ^{[1
]}

机构：

[1] Univ Calgary, Dept Physiol & Pharmacol, Alberta Childrens Hosp, Res Inst,Hotchkiss Brain Inst,Cumming Sch Med, Calgary, AB, Canada

来源：

SCIENCE SIGNALING | 2019年 / 12卷 / 603期

关键词：

GABA;

D O I：

10.1126/scisignal.aay8960

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The K+/Cl- cotransporter KCC2 is a molecular switch between excitatory and inhibitory effects of GABAergic inputs into neurons. In a pair of exciting studies, Watanabe et al. and Pisella et al. elucidate the role of KCC2 dephosphorylation in this process and reveal its consequences for neurodevelopment and nervous system pathology.

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页数：2

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