Utilization and outcome of thrombolytic therapy for acute stroke in Pakistan

被引：26

作者：

Wasay, Mohammad ^{[1
]}

Barohi, Hazim ^{[1
]}

Malik, Abdul ^{[2
]}

Yousuf, Adnan ^{[1
]}

Awan, Safia ^{[1
]}

Kamal, Ayeesha K. ^{[1
]}

机构：

[1] Aga Khan Univ, Dept Neurol & Med, Karachi 74800, Pakistan

[2] Liaquat Natl Hosp, Dept Neurol, Karachi, Pakistan

来源：

NEUROLOGICAL SCIENCES | 2010年 / 31卷 / 02期

关键词：

Acute stroke; Thrombolysis; CT scan; r-tpa; ACUTE ISCHEMIC-STROKE; TISSUE-PLASMINOGEN ACTIVATOR;

D O I：

10.1007/s10072-009-0159-y

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Our objective was to identify the outcome of patients treated with tissue plasminogen activator (r-tPa) in Pakistan and compare these data to available regional and international data. The charts of all patients treated with r-tPa for acute stroke at two centers in Pakistan (Aga Khan University, Karachi and Liaquat National hospital, Karachi) were retrospectively reviewed. We identified 21 patients. The utilization of tPa at Aga Khan Hospital was 18/1,185 patients (1.5%) from 2005 to 2007 while at Liaquat National Hospital was 3/575 patients (0.52%) over 1 year (2007). Mean time interval between stroke onset and start of r-tPa infusion was 169 min. Three patients (14%) developed fatal hemorrhage and two (10%) developed non-fatal hemorrhage. Four patients (19%) died. We identified protocol violations in seven patients (33%). In conclusion, the utilization of thrombolytic therapy is low and complication rate is high. Interventions for training physicians are needed.

引用

页码：223 / 225

页数：3

共 14 条

[1]

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