Solubility of Benzodiazepines in Polyethylene Glycol 200+Water Mixtures at 303.2 K

被引：37

作者：

Jouyban, Abolghasem ^{[1
,2
]}

Shokri, Javad ^{[3
]}

Barzegar-Jalali, Mohammad ^{[3
]}

Hassanzadeh, Davoud ^{[4
]}

Acree, William E., Jr. ^{[5
]}

Ghafourian, Taravat ^{[6
,7
]}

Nokhodchi, Ali ^{[6
,7
]}

机构：

[1] Tabriz Univ Med Sci, Fac Pharm, Tabriz 51664, Iran

[2] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz 51664, Iran

[3] Tabriz Univ Med Sci, Biotechnol Res Ctr, Tabriz 51664, Iran

[4] Tabriz Univ Med Sci, Res Ctr Pharmaceut Nanotechnol, Tabriz 51664, Iran

[5] Univ N Texas, Dept Chem, Denton, TX 76203 USA

[6] Univ Kent, Medway Sch Pharm, Chatham ME4 4TB, Kent, England

[7] Univ Greenwich, Medway Sch Pharm, Chatham ME4 4TB, Kent, England

来源：

JOURNAL OF CHEMICAL AND ENGINEERING DATA | 2010年 / 55卷 / 01期

关键词：

PREDICTION; DRUGS;

D O I：

10.1021/je900330p

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

Experimental Solubilities of chlordiazepoxide, diazepam, and lorazepam in polyethylene glycol 200 (PEG 200) + water mixtures at 303.2 K were reported. The Solubility of each drug increased exponentially with the addition of PEG 200 and reached file maximum Value in neat PEG 200. The Jouyban-Acree model was used to mathematically describe the experimental data, and the Solubilities were predicted using a previously trained version of the Jouyban-Acree model for PEG + water Mixtures and the Solubility data in monosolvents. The overall mean relative deviations of the models were 3.7 % and 18.3 %, respectively, for the fitted model and the trained version.

引用

页码：519 / 522

页数：4

共 13 条

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