机构:
Univ Estado Rio de Janeiro, Inst Nutr, Dept Nutr Basica & Expt, BR-21941590 Rio De Janeiro, RJ, BrazilUniv Estado Rio de Janeiro, Inst Nutr, Dept Nutr Basica & Expt, BR-21941590 Rio De Janeiro, RJ, Brazil
Citelli, Marta
[1
]
Fonte-Faria, Thais
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h-index: 0
机构:
Univ Estado Rio de Janeiro, Inst Biol Roberto Alcantara Gomes, BR-20551030 Rio De Janeiro, RJ, BrazilUniv Estado Rio de Janeiro, Inst Nutr, Dept Nutr Basica & Expt, BR-21941590 Rio De Janeiro, RJ, Brazil
Fonte-Faria, Thais
[2
]
Nascimento-Silva, Vany
论文数: 0引用数: 0
h-index: 0
机构:
Univ Estado Rio de Janeiro, Inst Biol Roberto Alcantara Gomes, BR-20551030 Rio De Janeiro, RJ, BrazilUniv Estado Rio de Janeiro, Inst Nutr, Dept Nutr Basica & Expt, BR-21941590 Rio De Janeiro, RJ, Brazil
Nascimento-Silva, Vany
[2
]
Renovato-Martins, Mariana
论文数: 0引用数: 0
h-index: 0
机构:
Univ Estado Rio de Janeiro, Inst Biol Roberto Alcantara Gomes, BR-20551030 Rio De Janeiro, RJ, BrazilUniv Estado Rio de Janeiro, Inst Nutr, Dept Nutr Basica & Expt, BR-21941590 Rio De Janeiro, RJ, Brazil
Renovato-Martins, Mariana
[2
]
Silva, Raphael
论文数: 0引用数: 0
h-index: 0
机构:
Univ Estado Rio de Janeiro, Inst Nutr, Dept Nutr Basica & Expt, BR-21941590 Rio De Janeiro, RJ, BrazilUniv Estado Rio de Janeiro, Inst Nutr, Dept Nutr Basica & Expt, BR-21941590 Rio De Janeiro, RJ, Brazil
Silva, Raphael
[1
]
Luna, Aderval Severino
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h-index: 0
机构:
Univ Estado Rio de Janeiro, Inst Quim, BR-20551030 Rio De Janeiro, RJ, BrazilUniv Estado Rio de Janeiro, Inst Nutr, Dept Nutr Basica & Expt, BR-21941590 Rio De Janeiro, RJ, Brazil
Luna, Aderval Severino
[3
]
da Silva, Simone Vargas
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机构:
Univ Estado Rio de Janeiro, Inst Biol Roberto Alcantara Gomes, BR-20551030 Rio De Janeiro, RJ, BrazilUniv Estado Rio de Janeiro, Inst Nutr, Dept Nutr Basica & Expt, BR-21941590 Rio De Janeiro, RJ, Brazil
da Silva, Simone Vargas
[2
]
Barja-Fidalgo, Christina
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h-index: 0
机构:
Univ Estado Rio de Janeiro, Inst Biol Roberto Alcantara Gomes, BR-20551030 Rio De Janeiro, RJ, BrazilUniv Estado Rio de Janeiro, Inst Nutr, Dept Nutr Basica & Expt, BR-21941590 Rio De Janeiro, RJ, Brazil
Barja-Fidalgo, Christina
[2
]
机构:
[1] Univ Estado Rio de Janeiro, Inst Nutr, Dept Nutr Basica & Expt, BR-21941590 Rio De Janeiro, RJ, Brazil
[2] Univ Estado Rio de Janeiro, Inst Biol Roberto Alcantara Gomes, BR-20551030 Rio De Janeiro, RJ, Brazil
[3] Univ Estado Rio de Janeiro, Inst Quim, BR-20551030 Rio De Janeiro, RJ, Brazil
Hepcidin is a key hormone that induces the degradation of ferroportin (FPN), a protein that exports iron from reticuloendothelial macrophages and enterocytes. The aim of the present study was to experimentally evaluate if the obesity induced by a high-fat diet (HFD) modifies the expression of FPN in macrophages and enterocytes, thus altering the iron bioavailability. In order to directly examine changes associated with iron metabolism in vivo, C57BL/6J mice were fed either a control or a HFD. Serum leptin levels were evaluated. The hepcidin, divalent metal transporter-1 (DMT1), FPN and ferritin genes were analyzed by real-time polymerase chain reaction. The amount of iron present in both the liver and spleen was determined by flame atomic absorption spectrometry. Ferroportin localization within reticuloendothelial macrophages was observed by immunofluorescence microscopy. Obese animals were found to exhibit increased hepcidin gene expression, while iron accumulated in the spleen and liver. They also exhibited changes in the sublocation of splenic cellular FPN and a reduction in the FPN expression in the liver and the spleen, while no changes were observed in enterocytes. Possible explanations for the increased hepcidin expression observed in HFD animals may include: increased leptin levels, the liver iron accumulation or endoplasmic reticulum (ER) stress. Together, the results indicated that obesity promotes changes in iron bioavailability, since it altered the iron recycling function.
机构:
Paracelsus Med Univ, Dept Med 1, A-5020 Salzburg, Austria
Paracelsus Med Univ, Obes Res Unit, A-5020 Salzburg, AustriaParacelsus Med Univ, Dept Med 1, A-5020 Salzburg, Austria
Aigner, Elmar
;
Feldman, Alexandra
论文数: 0引用数: 0
h-index: 0
机构:
Paracelsus Med Univ, Dept Med 1, A-5020 Salzburg, AustriaParacelsus Med Univ, Dept Med 1, A-5020 Salzburg, Austria
Feldman, Alexandra
;
Datz, Christian
论文数: 0引用数: 0
h-index: 0
机构:
Paracelsus Med Univ, Obes Res Unit, A-5020 Salzburg, Austria
Gen Hosp, Dept Internal Med, A-5110 Oberndorf, AustriaParacelsus Med Univ, Dept Med 1, A-5020 Salzburg, Austria
机构:
Joslin Diabet Ctr, Sect Islet Cell Biol & Regenerat Med, Boston, MA 02215 USA
Harvard Univ, Sch Med, Boston, MA USAJoslin Diabet Ctr, Sect Islet Cell Biol & Regenerat Med, Boston, MA 02215 USA
Akiyama, Masaru
;
论文数: 引用数:
h-index:
机构:
Liew, Chong Wee
;
Lu, Shusheng
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Pharmacol, Ann Arbor, MI 48109 USA
Univ Illinois, Dept Physiol & Biophys, Chicago, IL 60680 USAJoslin Diabet Ctr, Sect Islet Cell Biol & Regenerat Med, Boston, MA 02215 USA
Lu, Shusheng
;
Hu, Jiang
论文数: 0引用数: 0
h-index: 0
机构:
Joslin Diabet Ctr, Sect Islet Cell Biol & Regenerat Med, Boston, MA 02215 USA
Harvard Univ, Sch Med, Boston, MA USAJoslin Diabet Ctr, Sect Islet Cell Biol & Regenerat Med, Boston, MA 02215 USA
Hu, Jiang
;
Martinez, Rachael
论文数: 0引用数: 0
h-index: 0
机构:
Joslin Diabet Ctr, Sect Islet Cell Biol & Regenerat Med, Boston, MA 02215 USA
Harvard Univ, Sch Med, Boston, MA USAJoslin Diabet Ctr, Sect Islet Cell Biol & Regenerat Med, Boston, MA 02215 USA
Martinez, Rachael
;
Hambro, Ben
论文数: 0引用数: 0
h-index: 0
机构:
Joslin Diabet Ctr, Sect Islet Cell Biol & Regenerat Med, Boston, MA 02215 USA
Harvard Univ, Sch Med, Boston, MA USAJoslin Diabet Ctr, Sect Islet Cell Biol & Regenerat Med, Boston, MA 02215 USA
Hambro, Ben
;
Kennedy, Robert T.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Pharmacol, Ann Arbor, MI 48109 USAJoslin Diabet Ctr, Sect Islet Cell Biol & Regenerat Med, Boston, MA 02215 USA
Kennedy, Robert T.
;
Kulkarni, Rohit N.
论文数: 0引用数: 0
h-index: 0
机构:
Joslin Diabet Ctr, Sect Islet Cell Biol & Regenerat Med, Boston, MA 02215 USA
Harvard Univ, Sch Med, Boston, MA USAJoslin Diabet Ctr, Sect Islet Cell Biol & Regenerat Med, Boston, MA 02215 USA
机构:
Paracelsus Med Univ, Dept Med 1, A-5020 Salzburg, Austria
Paracelsus Med Univ, Obes Res Unit, A-5020 Salzburg, AustriaParacelsus Med Univ, Dept Med 1, A-5020 Salzburg, Austria
Aigner, Elmar
;
Feldman, Alexandra
论文数: 0引用数: 0
h-index: 0
机构:
Paracelsus Med Univ, Dept Med 1, A-5020 Salzburg, AustriaParacelsus Med Univ, Dept Med 1, A-5020 Salzburg, Austria
Feldman, Alexandra
;
Datz, Christian
论文数: 0引用数: 0
h-index: 0
机构:
Paracelsus Med Univ, Obes Res Unit, A-5020 Salzburg, Austria
Gen Hosp, Dept Internal Med, A-5110 Oberndorf, AustriaParacelsus Med Univ, Dept Med 1, A-5020 Salzburg, Austria
机构:
Joslin Diabet Ctr, Sect Islet Cell Biol & Regenerat Med, Boston, MA 02215 USA
Harvard Univ, Sch Med, Boston, MA USAJoslin Diabet Ctr, Sect Islet Cell Biol & Regenerat Med, Boston, MA 02215 USA
Akiyama, Masaru
;
论文数: 引用数:
h-index:
机构:
Liew, Chong Wee
;
Lu, Shusheng
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Pharmacol, Ann Arbor, MI 48109 USA
Univ Illinois, Dept Physiol & Biophys, Chicago, IL 60680 USAJoslin Diabet Ctr, Sect Islet Cell Biol & Regenerat Med, Boston, MA 02215 USA
Lu, Shusheng
;
Hu, Jiang
论文数: 0引用数: 0
h-index: 0
机构:
Joslin Diabet Ctr, Sect Islet Cell Biol & Regenerat Med, Boston, MA 02215 USA
Harvard Univ, Sch Med, Boston, MA USAJoslin Diabet Ctr, Sect Islet Cell Biol & Regenerat Med, Boston, MA 02215 USA
Hu, Jiang
;
Martinez, Rachael
论文数: 0引用数: 0
h-index: 0
机构:
Joslin Diabet Ctr, Sect Islet Cell Biol & Regenerat Med, Boston, MA 02215 USA
Harvard Univ, Sch Med, Boston, MA USAJoslin Diabet Ctr, Sect Islet Cell Biol & Regenerat Med, Boston, MA 02215 USA
Martinez, Rachael
;
Hambro, Ben
论文数: 0引用数: 0
h-index: 0
机构:
Joslin Diabet Ctr, Sect Islet Cell Biol & Regenerat Med, Boston, MA 02215 USA
Harvard Univ, Sch Med, Boston, MA USAJoslin Diabet Ctr, Sect Islet Cell Biol & Regenerat Med, Boston, MA 02215 USA
Hambro, Ben
;
Kennedy, Robert T.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Pharmacol, Ann Arbor, MI 48109 USAJoslin Diabet Ctr, Sect Islet Cell Biol & Regenerat Med, Boston, MA 02215 USA
Kennedy, Robert T.
;
Kulkarni, Rohit N.
论文数: 0引用数: 0
h-index: 0
机构:
Joslin Diabet Ctr, Sect Islet Cell Biol & Regenerat Med, Boston, MA 02215 USA
Harvard Univ, Sch Med, Boston, MA USAJoslin Diabet Ctr, Sect Islet Cell Biol & Regenerat Med, Boston, MA 02215 USA