Bronsted Acid-Catalyzed Intramolecular Hydroarylation of β-Benzylstyrenes

被引：25
|
作者：
Cai, Xiao [1 ]
Keshavarz, Amir [1 ]
Omaque, Justin D. [1 ]
Stokes, Benjamin J. [1 ]
机构：
[1] Univ Calif Merced, Sch Nat Sci, 5200 North Lake Rd, Merced, CA 95343 USA
来源：
ORGANIC LETTERS | 2017年 / 19卷 / 10期
关键词：
RING-CLOSURE; STEREOSELECTIVE-SYNTHESIS; FUNCTIONALIZED INDANES; FLUOROSULFURIC ACID; ALKENES; CYCLIZATION; ALKYLATION; CARBINOLS; ESTERS; CATION;
D O I：
10.1021/acs.orglett.7b00958
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Using triphenylmethylium tetrakis(pentafluorophenyl)borate as a convenient Bronsted acid precatalyst, beta-(alpha,alpha-dimethylbenzyl)styrenes are shown to cyclize efficiently to afford a variety of new indanes that possess a benzylic quaternary center. The geminal dimethyl-containing quaternary center is proposed to be necessary to arm the substrate for cyclization through steric biasing.
引用
收藏
页码：2626 / 2629
页数：4
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