Enantioselective Rhodium(III)-Catalyzed Markovnikov Hydroboration of Unactivated Terminal Alkenes

被引：96

作者：

Smith, James R. ^{[1
]}

Collins, Beatrice S. L. ^{[1
]}

Hesse, Matthew J. ^{[1
]}

Graham, Mark A. ^{[2
]}

Myers, Eddie L. ^{[1
]}

Aggarwal, Varinder K. ^{[1
]}

机构：

[1] Univ Bristol, Sch Chem, Cantocks Close, Bristol BS8 1TS, Avon, England

[2] AstraZeneca, Pharmaceut Technol & Dev, Silk Rd Business Pk,Charter Way, Macclesfield SK10 2NA, Cheshire, England

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2017年 / 139卷 / 27期

基金：

英国工程与自然科学研究理事会; 欧盟地平线“2020”;

关键词：

CATALYTIC ASYMMETRIC HYDROBORATION; TERTIARY BORONIC ESTERS; 1,1-DISUBSTITUTED ALKENES; TRISUBSTITUTED ALKENES; PINACOLBORANE; DIBORATION; BORATION; HYDROFUNCTIONALIZATION; DESYMMETRIZATION; SELECTIVITY;

D O I：

10.1021/jacs.7b05149

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the first enantioselective Rh-catalyzed Markovnikov hydroboration of unactivated terminal alkenes. Using a novel sp(2)-sp(3) hybridized diboron reagent and water as a proton source, a broad range of alkenes undergo hydroboration to provide secondary boronic esters with high regio- and enantiocontrol.

引用

页码：9148 / 9151

页数：4

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