Vesicular Stomatitis Virus-Based Vaccines against Lassa and Ebola Viruses

被引：140

作者：

Marzi, Andrea ^{[1
]}

Feldmann, Friederike ^{[1
]}

Geisbert, Thomas W. ^{[2
]}

Feldmann, Heinz ^{[1
]}

Safronetz, David ^{[1
]}

机构：

[1] NIH, Hamilton, MT 59840 USA

[2] Univ Texas Med Branch, Galveston, TX 77555 USA

来源：

EMERGING INFECTIOUS DISEASES | 2015年 / 21卷 / 02期

基金：

美国国家卫生研究院;

关键词：

PROTECTS NONHUMAN-PRIMATES; ANTIBODIES; GLYCOPROTEINS; CHALLENGE; DISEASE;

D O I：

10.3201/eid2102.141649

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We demonstrated that previous vaccination with a vesicular stomatitis virus (VSV) based Lassa virus vaccine does not alter protective efficacy of subsequent vaccination with a VSV-based Ebola virus vaccine. These findings demonstrate the utility of VSV-based vaccines against divergent viral pathogens, even when preexisting immunity to the vaccine vector is present.

引用

页码：305 / 307

页数：3

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