Synergetic Catalytic Bleaching Earth Clay and PEG-400 for Rapid Synthesis of Polyhydroquinoline Derivatives and Their 2,2-Diphyenyl-1-picrylhydrazyl Radical Scavenging Activity

被引：0

作者：

Raithak, Pranita, V ^{[1
]}

Dhabe, Arvind S. ^{[1
]}

Atkore, Sandeep T. ^{[2
]}

Alam, M. Mujahid ^{[3
]}

Kotra, Vijay ^{[4
]}

Varala, Ravi ^{[5
]}

机构：

[1] Dr Babasaheb Ambedkar Marathwada Univ, Dept Bot, Aurangabad, Maharashtra, India

[2] Dr Babasaheb Ambedkar Marathwada Univ, Dept Biochem, Aurangabad, Maharashtra, India

[3] King Khalid Univ, Coll Sci, Dept Chem, Abha 61413, Saudi Arabia

[4] Quest Int Univ, Fac Pharm, Ipoh, Malaysia

[5] Scrips Pharma, Hyderabad, Telangana, India

来源：

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2022年 / 32卷 / 01期

关键词：

Bleaching earth clay; PEG-400; Polyhydroquinoline; Aldehydes; 2,2-Diphyenyl-1-pierylhydrazyl; POLYETHYLENE-GLYCOL PEG-400; ONE-POT SYNTHESIS; GREEN SYNTHESIS; HANTZSCH 1,4-DIHYDROPYRIDINES; MULTICOMPONENT REACTIONS; HETEROGENEOUS CATALYST; CALCIUM-ANTAGONISM; PH; 12.5; EFFICIENT; ANTIOXIDANT;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Polyhydroquinoline derivatives have been efficiently synthesized via one-pot condensation of ethyl acetoacetate, dimedone, NH4OAc, and the substituted aromatic aldehyde using cost-effective synergetic catalytic system basic bleaching earth clay and PEG-400. The highlight of present protocol includes catalyst recyclability, excellent yield, shorter reaction time, and use of green catalyst and solvent. Synthesized derivatives were also screened for their antioxidant activity was evaluated by 2,2-diphyenyl-l-picrylhydrazyl radical scavenging assay methods.

引用

页码：85 / 90

页数：6

共 48 条

[1] "Green synthesis" of benzothiazepine library of indeno analogues and their in vitro antimicrobial activity [J].

Acharya, Ashok P. ;

Kamble, Rahul D. ;

Patil, Snehalkumar D. ;

Hese, Shrikant V. ;

Yemul, Omprakash S. ;

Patil, Sudhakar G. ;

Halale, Shivshankar N. ;

Dawane, Bhaskar S. .

CHEMICAL PAPERS, 2014, 68 (05) :719-724

[2] One-pot syntheses of 5-oxo-1,4,5,6,7,8-hexahydroquinolines and pyrimido[4,5-b]quinolines using microwave irradiation and ultrasound [J].

Ahluwalia, VK ;

Goyal, B ;

Das, U .

JOURNAL OF CHEMICAL RESEARCH-S, 1997, (07) :266-&

[3] Zn(OAc)2•2H2O-Catalyzed Betti Base Synthesis under Solvent-free Conditions [J].

Alam, M. Mujahid ;

Bollikolla, Hari B. ;

Varala, Ravi .

LETTERS IN ORGANIC CHEMISTRY, 2022, 19 (01) :14-18

[4] Synthesis of 1,2-Dihydro-Substituted Aniline Analogues Involving N-Phenyl-3-aza-Cope Rearrangement Using a Metal-Free Catalytic Approach [J].

Alduhaish, Osamah ;

Varala, Ravi ;

Adil, Syed Farooq ;

Khan, Mujeeb ;

Siddiqui, Mohammed Rafiq H. ;

AlWarthan, Abdulrhman ;

Alam, M. Mujahid .

JOURNAL OF CHEMISTRY, 2020, 2020

[5]

Arumugam P, 2008, INDIAN J CHEM B, V47, P1084

[6] An efficient PEG-400 mediated catalyst free green synthesis of 2-amino-thiazoles from α-diazoketones and thiourea [J].

Babu, B. Hari ;

Vijay, K. ;

Krishna, K. Bala Murali ;

Sharmila, N. ;

Ramana, M. Baby .

JOURNAL OF CHEMICAL SCIENCES, 2016, 128 (09) :1475-1478

[7] In vitro antioxidant activity of red grape skins [J].

Bartolomé, B ;

Nuñez, V ;

Monagas, M ;

Gómez-Cordovés, C .

EUROPEAN FOOD RESEARCH AND TECHNOLOGY, 2004, 218 (02) :173-177

[8]

Boer Rainer, 1995, Drugs of the Future, V20, P499

[9] 4-ARYLDIHYDROPYRIDINES, A NEW CLASS OF HIGHLY-ACTIVE CALCIUM-ANTAGONISTS [J].

BOSSERT, F ;

MEYER, H ;

WEHINGER, E .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1981, 20 (09) :762-769

[10] Solid-phase synthesis of 4-aryl-1,4-dihydropyridines via the Hantzsch three component condensation [J].

Breitenbucher, JG ;

Figliozzi, G .

TETRAHEDRON LETTERS, 2000, 41 (22) :4311-4315

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