Therapeutic Effect of Curcumin in Women with Polycystic Ovary Syndrome Receiving Metformin: A Randomized Controlled Trial

被引：20

作者：

Sohrevardi, Seyed Mojtaba ^{[1
,2
]}

Heydari, Behrooz ^{[1
]}

Azarpazhooh, Mahmoud Reza ^{[3
,4
]}

Teymourzadeh, Mohammad ^{[1
]}

Simental-Mendia, Luis E. ^{[5
]}

Atkin, Stephen L. ^{[6
]}

Sahebkar, Amirhossein ^{[7
,8
,9
,10
]}

Karimi-Zarchi, Mojgan ^{[11
]}

机构：

[1] Shahid Sadoughi Univ Med Sci, Fac Pharm, Pharmaceut Sci Res Ctr, Yazd, Iran

[2] Univ Western Ontario, Stroke Prevent & Atherosclerosis Res Ctr, London, ON, Canada

[3] Univ Western Ontario, Dept Clin Neurol Sci, London, ON, Canada

[4] Univ Western Ontario, Dept Epidemiol & Biostat, London, ON, Canada

[5] Mexican Social Secur Inst, Biomed Res Unit, Durango, Mexico

[6] Weill Cornell Med Qatar, Doha, Qatar

[7] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Razavi Khorasan, Iran

[8] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Razavi Khorasan, Iran

[9] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Razavi Khorasan, Iran

[10] Polish Mothers Mem Hosp Res Inst PMMHRI, Lodz, Poland

[11] Iran Univ Med Sci, Dept Gynecol & Obstet, Tehran, Iran

来源：

PHARMACOLOGICAL PROPERTIES OF PLANT-DERIVED NATURAL PRODUCTS AND IMPLICATIONS FOR HUMAN HEALTH | 2021年 / 1308卷

关键词：

Nanomicelle curcumin; Metformin; Polycystic ovary syndrome; BLOOD-GLUCOSE; DOUBLE-BLIND;

D O I：

10.1007/978-3-030-64872-5_9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility, for which the insulin sensitizer metformin has been used therapeutically. It has been shown that curcumin also exhibits insulin-sensitizing properties. Given that metformin acts as an ovulation inducing agent and both curcumin and metformin can reduce insulin resistance, the aim of the current study was to evaluate the effect of metformin with and without curcumin nanomicelles in the treatment of women with polycystic ovary syndrome. This clinical trial was conducted on 100 women with PCOS, diagnosed according to the Rotterdam criteria, who were sequentially recruited and randomly divided into two groups (n = 50 each). Group 1 received 500 mg metformin three times daily and group 2 received 80 mg/day capsule of curcumin nanomicelle and 500 mg metformin three times a day for 3 months. After collecting fasting blood samples, biochemical parameters including triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol, plasma glucose, alanine amino transferase (ALT) and aspartate aminotransferase (AST) were evaluated based on enzymatic methods. Hormonal parameters were assessed using immunoassay kits. Insulin resistance (HOMA-IR) and insulin-sensitivity check index (QUICKI) were also assessed. After treatment, fasting insulin, HOMA-IR, and total testosterone in group 2 were significantly lower than those in group 1 (p < 0.05). Post-treatment LDL-C levels in groups 1 and 2 were 117.9 +/- 24 and 91.12 +/- 19.46 mg/dL, respectively (p < 0.01). In addition, HDL-C levels were increased with curcumin (group 1: 38.1 +/- 4.36 mg/dL; group 2: 44.12 +/- 7.3 mg/dL, p < 0.05). Total cholesterol was decreased with curcumin level (group 1: 207.9 +/- 39.84 mg/dL; group 2; 159.7 +/- 48.43 mg/dL, p < 0.05), with a decrease in triglycerides levels (group 1: 141.6 +/- 9.57; group 2: 97.5 +/- 8.8 mg/dL, p < 0.01). This study showed that curcumin has a synergistic effect with metformin in the improvement of insulin resistance and lipid profile in patients with PCOS. Therefore, the combined use of metformin and curcumin may have therapeutic utility in patients with PCOS.

引用

页码：109 / 117

页数：9