On the Effect of Temperature on Aqueous Solubility of Organic Solids

被引：22
作者：
Black, Simon [1 ]
Muller, Frans [1 ]
机构：
[1] AstraZeneca, Pharmaceut Dev, Macclesfield SK10 2NA, Cheshire, England
来源：
ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2010年 / 14卷 / 03期
关键词：
D O I：
10.1021/op100006y
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The variation of solubility with temperature in water is an important consideration in the design of crystallizations and other processes. Solubility was found to vary exponentially with temperature (in degrees C) for a literature data set of 50 organic molecules in water. This complements a similar recent finding for the solubility of organic molecules in organic solvents. The 'solubility doubling temperature' is a convenient way to express this variation and provides a numerical link between enthalpy of dissolution and yield. The 'solubility doubling temperature' in water varies with solute, and the median value from this data set is 21.4 degrees C, consistent with 'Black's rule'.
引用
收藏
页码：661 / 665
页数：5
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