Electrochemical Analysis of Dopamine: Perspectives of Specific In Vivo Detection

被引：97

作者：

Ferapontova, Elena E. ^{[1
]}

机构：

[1] Aarhus Univ, Interdisciplinary Nanosci Ctr iNANO, Gustav Wieds Vej 1590-14, DK-8000 Aarhus C, Denmark

来源：

ELECTROCHIMICA ACTA | 2017年 / 245卷

基金：

新加坡国家研究基金会;

关键词：

Electroanalysis; dopamine; catechol amines; carbon microfiber electrodes; enzyme electrodes; aptamer electrodes; CARBON ELECTRODES; EXOCYTOTIC EVENTS; RELEASE; VOLTAMMETRY; BIOSENSOR; NEUROTRANSMITTERS; MICROELECTRODES; CATECHOLS; SENSORS; ACID;

D O I：

10.1016/j.electacta.2017.05.183

中图分类号：

O646 [电化学、电解、磁化学];

学科分类号：

081704 ;

摘要：

Direct electrochemical analysis of in vivo levels of dopamine, whose metabolic transformation in the brain can be correlated with a number of neurodegenerative disorders such as Parkinson's and Alzheimer's diseases as well as psychosis and drug addiction, allows studying their mechanisms and the ways they can be treated. However, direct electrochemical analysis of dopamine can often be masked by electrochemical responses from structurally related neurotransmitters, dopamine precursors and products of its metabolic transformation, whose redox potentials overlap with those of dopamine. In this mini-review, the state-of-the-art in the field and recent trends in specific electroanalysis of dopamine in the presence of structurally related neurotransmitters are reviewed and critically discussed. (C) 2017 Elsevier Ltd. All rights reserved.

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页码：664 / 671

页数：8

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