Foamy virus vectors

被引：141
作者：
Russell, DW
Miller, AD
机构：
[1] FRED HUTCHINSON CANC RES CTR,SEATTLE,WA 98104
[2] UNIV WASHINGTON,DIV HEMATOL,SEATTLE,WA 98195
[3] UNIV WASHINGTON,DEPT PATHOL,SEATTLE,WA 98195
来源：
JOURNAL OF VIROLOGY | 1996年 / 70卷 / 01期
关键词：
D O I：
10.1128/JVI.70.1.217-222.1996
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Human foamy virus (HFV) is a retrovirus of the spumavirus family, We have constructed vectors based on HFV that encode neomycin phosphotransferase and alkaline phosphatase. These vectors are able to transduce a wide variety of vertebrate cells by integration of the vector genome, Unlike vectors based on murine leukemia virus, HFV vectors are not inactivated by human serum, and they transduce stationary-phase cultures more efficiently than murine leukemia virus vectors. These properties, as well as their large packaging capacity, make HFV vectors promising gene transfer vehicles.
引用
收藏
页码：217 / 222
页数：6
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