The Mouse Hospital and Its Integration in Ultra-Precision Approaches to Cancer Care

被引:18
作者
Clohessy, John G. [1 ,2 ,3 ]
Pandol, Pier Paolo [3 ]
机构
[1] Harvard Med Sch, Preclin Murine Pharmacogenet Facil, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA
[2] Harvard Med Sch, Mouse Hosp, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA
[3] Harvard Med Sch, Dept Pathol & Med, Beth Israel Deaconess Med Ctr, Canc Res Inst, Boston, MA 02115 USA
来源
FRONTIERS IN ONCOLOGY | 2018年 / 8卷
关键词
mouse models; PDX; precision medicine; cancer; Mouse Hospital; Co-Clinical Trial; MODELS; MICE; CRISPR-CAS9; XENOGRAFTS; ORGANOIDS; BIOBANK; CELL;
D O I
10.3389/fonc.2018.00340
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Precision medicine holds real promise for the treatment of cancer. Adapting therapeutic strategies so patients receive individualized treatment protocols, will transform how diseases like cancer are managed. Already, molecular pro fi ling technologies have provided unprecedented capacity to characterize tumors, yet the ability to translate this to actionable outcome in the clinic is limited. To enable real time translation of personalized therapeutic approaches to patient care in a co-clinical manner will require the adoption and integration of approaches that facilitate modeling of patient disease. The Mouse Hospital represents an approach that is ideally suited to pre- and co-clinical evaluation of novel therapeutic strategies for clinical care. Patient derived xenograft (PDX) technologies and in situ tumor modeling approaches using genetically engineered mouse models (GEMMs) already have a proven capacity to mimic human tumor responses, and their application can deliver invaluable insights into appropriate clinical approaches for individual patients by mirroring human clinical trials using a Co-Clinical Trial project and Mouse Hospital infrastructure. Additionally, the integration of the Mouse Hospital with other emerging technologies for the application of precision medicines, including organoid technologies, provides a platform that enables medical centers to truly reap the bene fits that precision medicine has to offer.
引用
收藏
页数:6
相关论文
共 41 条
[1]   Modeling invasive lobular breast carcinoma by CRISPR/Cas9-mediated somatic genome editing of the mammary gland [J].
Annunziato, Stefano ;
Kas, Sjors M. ;
Nethe, Micha ;
Yucel, Hatice ;
Del Bravo, Jessica ;
Pritchard, Colin ;
Bin Ali, Rahmen ;
van Gerwen, Bas ;
Siteur, Bjorn ;
Drenth, Anne Paulien ;
Schut, Eva ;
van de Ven, Marieke ;
Boelens, Mirjam C. ;
Klarenbeek, Sjoerd ;
Huijbers, Ivo J. ;
van Miltenburg, Martine H. ;
Jonkers, Jos .
GENES & DEVELOPMENT, 2016, 30 (12) :1470-1480
[2]   The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity [J].
Barretina, Jordi ;
Caponigro, Giordano ;
Stransky, Nicolas ;
Venkatesan, Kavitha ;
Margolin, Adam A. ;
Kim, Sungjoon ;
Wilson, Christopher J. ;
Lehar, Joseph ;
Kryukov, Gregory V. ;
Sonkin, Dmitriy ;
Reddy, Anupama ;
Liu, Manway ;
Murray, Lauren ;
Berger, Michael F. ;
Monahan, John E. ;
Morais, Paula ;
Meltzer, Jodi ;
Korejwa, Adam ;
Jane-Valbuena, Judit ;
Mapa, Felipa A. ;
Thibault, Joseph ;
Bric-Furlong, Eva ;
Raman, Pichai ;
Shipway, Aaron ;
Engels, Ingo H. ;
Cheng, Jill ;
Yu, Guoying K. ;
Yu, Jianjun ;
Aspesi, Peter, Jr. ;
de Silva, Melanie ;
Jagtap, Kalpana ;
Jones, Michael D. ;
Wang, Li ;
Hatton, Charles ;
Palescandolo, Emanuele ;
Gupta, Supriya ;
Mahan, Scott ;
Sougnez, Carrie ;
Onofrio, Robert C. ;
Liefeld, Ted ;
MacConaill, Laura ;
Winckler, Wendy ;
Reich, Michael ;
Li, Nanxin ;
Mesirov, Jill P. ;
Gabriel, Stacey B. ;
Getz, Gad ;
Ardlie, Kristin ;
Chan, Vivien ;
Myer, Vic E. .
NATURE, 2012, 483 (7391) :603-607
[3]   An Interactive Resource to Identify Cancer Genetic and Lineage Dependencies Targeted by Small Molecules [J].
Basu, Amrita ;
Bodycombe, Nicole E. ;
Cheah, Jaime H. ;
Price, Edmund V. ;
Liu, Ke ;
Schaefer, Giannina I. ;
Ebright, Richard Y. ;
Stewart, Michelle L. ;
Ito, Daisuke ;
Wang, Stephanie ;
Bracha, Abigail L. ;
Liefeld, Ted ;
Wawer, Mathias ;
Gilbert, Joshua C. ;
Wilson, Andrew J. ;
Stransky, Nicolas ;
Kryukov, Gregory V. ;
Dancik, Vlado ;
Barretina, Jordi ;
Garraway, Levi A. ;
Hon, C. Suk-Yee ;
Munoz, Benito ;
Bittker, Joshua A. ;
Stockwell, Brent R. ;
Khabele, Dineo ;
Stern, Andrew M. ;
Clemons, Paul A. ;
Shamji, Alykhan F. ;
Schreiber, Stuart L. .
CELL, 2013, 154 (05) :1151-1161
[4]   Patient-derived xenografts undergo mouse-specific tumor evolution [J].
Ben-David, Uri ;
Ha, Gavin ;
Tseng, Yuen-Yi ;
Greenwald, Noah F. ;
Oh, Coyin ;
Shih, Juliann ;
McFarland, James M. ;
Wong, Bang ;
Boehm, Jesse S. ;
Beroukhim, Rameen ;
Golub, Todd R. .
NATURE GENETICS, 2017, 49 (11) :1567-+
[5]   Can cancer researchers accurately judge whether preclinical reports will reproduce? [J].
Benjamin, Daniel ;
Mandel, David R. ;
Kimmelman, Jonathan .
PLOS BIOLOGY, 2017, 15 (06)
[6]   An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance [J].
Bester, Assaf C. ;
Lee, Jonathan D. ;
Chavez, Alejandro ;
Lee, Yu-Ru ;
Nachmani, Daphna ;
Vora, Suhani ;
Victor, Joshua ;
Sauvageau, Martin ;
Monteleone, Emanuele ;
Rinn, John L. ;
Provero, Paolo ;
Church, George M. ;
Clohessy, John G. ;
Pandolfi, Pier Paolo .
CELL, 2018, 173 (03) :649-+
[7]   Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms [J].
Bezzi, Marco ;
Seitzer, Nina ;
Ishikawa, Tomoki ;
Reschke, Markus ;
Chen, Ming ;
Wang, Guocan ;
Mitchell, Caitlin ;
Ng, Christopher ;
Katon, Jesse ;
Lunardi, Andrea ;
Signoretti, Sabina ;
Clohessy, John G. ;
Zhang, Jiangwen ;
Pandolfi, Pier Paolo .
NATURE MEDICINE, 2018, 24 (02) :165-+
[8]   Interrogating open issues in cancer precision medicine with patient-derived xenografts [J].
Byrne, Annette T. ;
Alferez, Denis G. ;
Amant, Frederic ;
Annibali, Daniela ;
Arribas, Joaquin ;
Biankin, Andrew V. ;
Bruna, Alejandra ;
Budinska, Eva ;
Caldas, Carlos ;
Chang, David K. ;
Clarke, Robert B. ;
Clevers, Hans ;
Coukos, George ;
Dangles-Marie, Virginie ;
Eckhardt, S. Gail ;
Gonzalez-Suarez, Eva ;
Hermans, Els ;
Hidalgo, Manuel ;
Jarzabek, Monika A. ;
de Jong, Steven ;
Jonkers, Jos ;
Kemper, Kristel ;
Lanfrancone, Luisa ;
Maelandsmo, Gunhild Mari ;
Marangoni, Elisabetta ;
Marine, Jean-Christophe ;
Medico, Enzo ;
Norum, Jens Henrik ;
Palmer, Hector G. ;
Peeper, Daniel S. ;
Pelicci, Pier Giuseppe ;
Piris-Gimenez, Alejandro ;
Roman-Roman, Sergio ;
Rueda, Oscar M. ;
Seoane, Joan ;
Serra, Violeta ;
Soucek, Laura ;
Vanhecke, Dominique ;
Villanueva, Alberto ;
Vinolo, Emilie ;
Bertotti, Andrea ;
Trusolino, Livio .
NATURE REVIEWS CANCER, 2017, 17 (04) :254-268
[9]   Mouse hospital and co-clinical trial project-from bench to bedside (vol 12, pg 491, 2015) [J].
Clohessy, John G. ;
Pandolfi, Pier Paolo .
NATURE REVIEWS CLINICAL ONCOLOGY, 2015, 12 (08) :498-498
[10]  
Clohessy John G, 2013, Cold Spring Harb Protoc, V2013, P1109, DOI 10.1101/pdb.top078782