Synthesis of new S-substituted derivatives of 5-[3-(1H-indol-3-yl)propyl]-1,3,4-oxadiazol-2-ylhydrosulfide as suitable antibacterial and anticancer agents with moderate cytotoxicity

被引：0

作者：

Nazir, Majid ^{[1
]}

Abbasi, Muhammad Athar ^{[1
]}

Aziz-ur-Rehman ^{[1
]}

Siddiqui, Sabahat Zahra ^{[1
]}

Shah, Syed Adnan Ali ^{[2
,3
]}

Shahid, M. ^{[4
]}

Fatima, H. ^{[4
]}

Iftikhar, Sunniya ^{[5
]}

Saleem, Rahman Shah Zaib ^{[5
]}

机构：

[1] Govt Coll Univ, Dept Chem, Lahore, Pakistan

[2] Univ Teknol MARA, Fac Pharm, Level 9,FF3,Punca kAlam Campus, Bandar Punca Kalam, Selangor Darul, Malaysia

[3] Univ Teknol MARA, Atta Ur Rahman Inst Nat Prod Discovery AuRIns, Level 9,FF3,Punca kAlam Campus, Bandar Punca Kalam, Selangor Darul, Malaysia

[4] Univ Agr Faisalabad, Dept Biochem, Faisalabad, Pakistan

[5] Lahore Univ Management Sci, Dept Chem & Chem Engn, SBA Sch Sci & Engn, Lahore, Pakistan

来源：

PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2019年 / 32卷 / 06期

关键词：

5-[3-(1H-indol-3-yl)propyl]-1,3,4-oxadiazol-2-yl hydro sulfide; alkyl/aralkyl halides; bacterial biofilm inhibition; antibacterial; anticancer; cytotoxicity; INHIBITION; DESIGN;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the study presented here, the nucleophilic substitution reaction of 5-[3-(1H-indol-3-yl)propyl]-1,3,4-oxadiazol-2-ylhydrosulfide was carried out with different alkyl/aralkyl halides (5a-r) to form its different S-substituted derivatives (6a-r), as depicted in scheme 1. The structural confirmation of all the synthesized compounds was done by IR, H-1-NMR, C-13-NMR and CHN analysis data. Bacterial biofilm inhibitory activity of all the synthesized compounds was carried out against Bacillus subtilis and Escherichia coli. The anticancer activity of these molecules was ascertained using anti-proliferation (SRB) assay on HCT 116 Colon Cancer Cell lines while the cytotoxicity of these molecules was profiled for their haemolytic potential. From this investigation it was rational that most of the compounds exhibited suitable antibacterial and anticancer potential along with a temperate cytotoxicity.

引用

页码：2585 / 2597

页数：13

共 26 条

[1]

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