Inhibition of shear-induced platelet aggregation by Chinese herbal medicines

被引：1

作者：

Liao, FL

Li, B

机构：

[1] Chinese Acad Tradit Chinese Med, Inst Chinese Mat Med, Beijing 100700, Peoples R China

[2] Beijing Xuanwu Hosp, Beijing Geriatr Clin & Res Ctr, Beijing 100053, Peoples R China

来源：

CLINICAL HEMORHEOLOGY AND MICROCIRCULATION | 1997年 / 17卷 / 04期

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Shear-induced platelet aggregation (SIPA) plays an important role in vascular diseases. In this study, SIPA was generated by a computerized cone-plate apparatus. Six compounds from Chinese herbal medicine were selected for in vitro and in vivo tests. Rabbit and rat were involved in the tests accordingly. Ligustrazine hydrochloridi appeared to be most effective for inhibition of SIPA. The inhibition rate of SIPA reached 44.2% (p < 0.01) for an in vitro concentration of 1 mg/ml, and 46.1% (p < 0.01) for an in vivo dose of 50 mg/kg.

引用

页码：315 / 318

页数：4